The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development.
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Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development.
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Similar dose sensitive responses to levels of EDA signaling are seen in tooth development of the mouse regulating the number and shape of teeth.
“Similar dose sensitive responses to levels of EDA signaling are seen in tooth development of the mouse regulating the number and shape of teeth [48],[49].”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [48]
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Kere, J., Srivastava, A. K., Montonen, O., Zonana, J., Thomas, N., Ferguson, B., Munoz, F., Morgan, D., Clarke, A., Baybayan, P., et al. (1996) · Nature Genetics · doi:10.1038/ng0895-409 · Cited by 749 · see citing works
Gene defect in ectodermal dysplasia implicates a death domain adapter in development
Headon, D. J., Emmal, S. A., Ferguson, B. M., Tucker, A. S., Justice, M. J., Sharpe, P. T., Zonana, J., & Overbeek, P. A. (2001) · Nature · doi:10.1038/414913a · Cited by 378 · see citing works
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Research works printed but not linked: 3
- Pirinen, S., 1998. Dental and oral aspects in anhidrotic ectodermal dyspla- sia. In: Bergendahl, B., Koch, G., Kurol, J., Wanndahl, G. (Eds.), Con- sensus Conference on Ectodermal Dysplasia with special reference to Dental Treatment. Forlagshuset Gothia AB, Stockholm, pp. 13 -21.
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Fraser, G. J., Hulsey, C. D., Bloomquist, R. F., Uyesugi, K., Manley, N. R., & Streelman, J. T. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000031 · Cited by 228 · see citing works
Harris, M. P., Rohner, N., Schwarz, H., Perathoner, S., Konstantinidis, P., & Nüsslein-Volhard, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000206 · Cited by 224 · see citing works
Overactivation of the NF‐κB pathway impairs molar enamel formation
Yamada, A., Kawasaki, M., Miake, Y., Yamada, Y., Blackburn, J., Kawasaki, K., Trakanant, S., Nagai, T., Nihara, J., Kudo, T., et al. (2020) · Oral Diseases · doi:10.1111/odi.13384 · Cited by 9 · see citing works
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- Authors
- Tucker, A. S., Headon, D. J., Courtney, J.-M., Overbeek, P., & Sharpe, P. T.
- Affiliations
- Guy's Hospital (GB)
- University of Manchester (GB)
- Baylor College of Medicine (US)
- Corresponding author
- Sharpe, P.T
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 268
- Issue
- 1
- Pages
- 185-194
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2096819604
- Cited by
- 146
- References
- 2
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 12 · 2013: 16 · 2012: 6
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3430 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- EDAR, cusp number, number of teeth, tooth development, ectodermal dysplasia, supernumerary teeth, molars, keratin 14 promoter, transgenic rescue
- MeSH terms
- Animals, Base Sequence, Dental Enamel, Humans, Membrane Proteins, Mice, Transgenic, Tooth, DNA Primers, Receptors, Tumor Necrosis Factor, Mice, Receptors, Ectodysplasin, Edar Receptor
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