The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Differences between human and mouse embryonic stem cells
Open accessAbstract
We compared gene expression profiles of mouse and human ES cells by immunocytochemistry, RT-PCR, and membrane-based focused cDNA array analysis. Several markers that in concert could distinguish undifferentiated ES cells from their differentiated progeny were identified. These included known markers such as SSEA antigens, OCT3/4, SOX-2, REX-1 and TERT, as well as additional markers such as UTF-1, TRF1, TRF2, connexin43, and connexin45, FGFR-4, ABCG-2, and Glut-1. A set of negative markers that confirm the absence of differentiation was also developed. These include genes characteristic of trophoectoderm, markers of germ layers, and of more specialized progenitor cells. While the expression of many of the markers was similar in mouse and human cells, significant differences were found in the expression of vimentin, beta-III tubulin, alpha-fetoprotein, eomesodermin, HEB, ARNT, and FoxD3 as well as in the expression of the LIF receptor complex LIFR/IL6ST (gp130). Profound differences in cell cycle regulation, control of apoptosis, and cytokine expression were uncovered using focused microarrays. The profile of gene expression observed in H1 cells was similar to that of two other human ES cell lines tested (line I-6 and clonal line-H9.2) and to feeder-free subclones of H1, H7, and H9, indicating that the observed differences between human and mouse ES cells were species-specific rather than arising from differences in culture conditions.
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Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 2×
“Telomerase was measured using the telomeric repeat amplification protocol (TRAP) assay as described (Kim et al., 1994; Weinrich et al., 1997), Terminal restriction fragment (TRF) size was determined using Southern hybridization as described (Allsopp et al.”
MethodTelomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086
Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2
Broccoli, D., Smogorzewska, A., Chong, L., & de Lange, T. (1997) · Nature Genetics · doi:10.1038/ng1097-231 · Cited by 926
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“Expression of TERT, TERF1, and TERF2 genes in both mouse ES and human ES was consistent with high telomerase activity measured with TRAP assay.”
BackgroundInfluentialNishio, K., Inoue, A., Qiao, S., Kondo, H., & Mimura, A. (2001) · Histochemistry and Cell Biology · doi:10.1007/s004180100325 · Cited by 115
Cited by
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
Initiative, T. I. S. C. (2007) · Nature Biotechnology · doi:10.1038/nbt1318 · Cited by 1,073
Specification of motoneurons from human embryonic stem cells
Li, X.-J., Du, Z.-W., Zarnowska, E. D., Pankratz, M., Hansen, L. O., Pearce, R. A., & Zhang, S.-C. (2005) · Nature Biotechnology · doi:10.1038/nbt1063 · Cited by 772
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
Rodin, S., Domogatskaya, A., Ström, S., Hansson, E. M., Chien, K. R., Inzunza, J., Hovatta, O., & Tryggvason, K. (2010) · Nature Biotechnology · doi:10.1038/nbt.1620 · Cited by 553
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
Takahashi-Yanaga, F., & Kahn, M. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2943 · Cited by 499
Derivation of induced pluripotent stem cells from pig somatic cells
Ezashi, T., Telugu, B. P. V. L., Alexenko, A. P., Sachdev, S., Sinha, S., & Roberts, R. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905284106 · Cited by 484
Metadata
- Authors
- Ginis, I., Luo, Y., Miura, T., Thies, S., Brandenberger, R., Gerecht-Nir, S., Amit, M., Hoke, A., Carpenter, M. K., Itskovitz-Eldor, J., & Rao, M. S.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 269
- Issue
- 2
- Pages
- 360-380
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2083763893
- Cited by
- 717
- References
- 9
- FWCI
- 21.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ginis, I., Luo, Y., Miura, T., Thies, S., Brandenberger, R., Gerecht-Nir, S., Amit, M., Hoke, A., Carpenter, M. K., Itskovitz-Eldor, J., & Rao, M. S. (2004). Differences between human and mouse embryonic stem cells. Developmental Biology. https://doi.org/10.1016/j.ydbio.2003.12.034
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