The echinoderm adhesome
Open accessAbstract
Although the development of sea urchin embryos has been studied extensively and clearly involves both cell adhesion and cell migration, rather little is known about the adhesion receptors and extracellular matrix molecules involved. The completion of the genome of Strongylocentrotus purpuratus allows a comprehensive survey of the complement of cell-cell and cell-matrix adhesion molecules in this organism. Furthermore, the phylogenetic position of echinoderms offers the opportunity to compare the complement of adhesion proteins between protostome and deuterostome invertebrates and between invertebrate and vertebrate deuterostomes. Many aspects of development and cell interactions differ among these different taxa and it is likely that analysis of the spectrum of adhesion receptors and extracellular matrix proteins can open up new insights into which molecules have evolved to suit particular developmental processes. In this paper, we report the results of an initial analysis along these lines. The echinoderm adhesome (complement of adhesion-related genes/proteins) is similar overall to that of other invertebrates although there are significant deuterostome-specific innovations and some interesting features previously thought to be chordate or vertebrate specific.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are large expansions of other LRR receptor families in the sea urchin, including GPCRs.
“In addition to the expansion of TLRs and NLRs mentioned above, there are large expansions of other LRR receptor families, including GPCRs (32).”
From The Genome of the Sea Urchin <i>Strongylocentrotus purpuratus</i> (2006) · cites this paper as [32]
Quite a few ECM proteins present in chordates but not protostomes are missing in sea urchins, including fibronectins, tenascins, von Willebrand factor, vitronectin, most vertebrate-type matrix proteoglycans, and complex VWA/FN3 collagens.
“Quite a few ECM proteins present in chordates, but not protostomes, were also missing in sea urchins, including fibronectins, tenascins, von Willebrand factor, vitronectin, most vertebrate-type matrix proteoglycans, and complex VWA/FN3 collagens among others (32).”
From The Genome of the Sea Urchin <i>Strongylocentrotus purpuratus</i> (2006) · cites this paper as [32]
Sea urchin rhodopsin-type GPCRs contain clear counterparts of functionally characterized GPCRs.
“Besides the Opsins, the rhodopsin-type sea urchin GPCRs contain other clear counterparts of functionally characterized GPCRs (Burke et al., 2006;Whittaker et al., 2006, and see below).”
From Opsins and clusters of sensory G-protein-coupled receptors in the sea urchin genome (2006) · cites this paper as Whittaker et al., 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 65 · Cited by 183
- Authors
- Whittaker, C. A., Bergeron, K.-F., Whittle, J., Brandhorst, B. P., Burke, R. D., & Hynes, R. O.
- Affiliations
- Massachusetts Institute of Technology (US)
- Simon Fraser University (CA)
- University of Victoria (CA)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Hynes, Richard O.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 300
- Issue
- 1
- Pages
- 252-266
- ISSN
- 0012-1606 (ISSN-L)
- PMC
- PMC3565218
- OpenAlex
- W2123647329
- Cited by
- 183
- References
- 65
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 16 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 3 · 2013: 11 · 2012: 15
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Keywords
- adhesome, cell adhesion receptors, extracellular matrix proteins, Strongylocentrotus purpuratus, sea urchin development, cell migration, deuterostome evolution, gene family evolution
- MeSH terms
- Animals, Cell Adhesion, Collagen, Echinodermata, Laminin, Models, Molecular, Phylogeny, Porifera, Protein Conformation, Sea Urchins, Protein Subunits
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
