Co-option of an anteroposterior head axis patterning system for proximodistal patterning of appendages in early bilaterian evolution
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The enormous diversity of extant animal forms is a testament to the power of evolution, and much of this diversity has been achieved through the emergence of novel morphological traits. The origin of novel morphological traits is an extremely important issue in biology, and a frequent source of this novelty is co-option of pre-existing genetic systems for new purposes (Carroll et al., 2008). Appendages, such as limbs, fins and antennae, are structures common to many animal body plans which must have arisen at least once, and probably multiple times, in lineages which lacked appendages. We provide evidence that appendage proximodistal patterning genes are expressed in similar registers in the anterior embryonic neurectoderm of Drosophila melanogaster and Saccoglossus kowalevskii (a hemichordate). These results, in concert with existing expression data from a variety of other animals suggest that a pre-existing genetic system for anteroposterior head patterning was co-opted for patterning of the proximodistal axis of appendages of bilaterian animals.
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Drosophila and vertebrate leg progenitor fields express the same set of regulatory genes in the same sequential order along the proximodistal axis, although as a result of different regulatory interactions.
“Thus, Drosophila and vertebrate leg progenitor fields express the same set of regulatory genes in the same sequential order along the proximodistal axis, although as a result of different regulatory interactions.”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Lemons et al., 2010
The Introduction (page unavailable) describes orthologous genes in Drosophila and vertebrate appendages, with broadly corresponding distal, medial, and proximal expression. It does not establish that the entire set is expressed in the same sequential order in both leg progenitor fields; it describes vertebrate Dach1 expression as complex. Nor does it show that the patterns result from different regulatory interactions. (LLM, conf=0.82)
Experimental — accuracy not yet measuredA similar interpretation has been applied to the apparent conservation of proximodistal patterning mechanisms in entirely non-homologous bilaterian appendages.
“A similar interpretation has been applied to the apparent conservation of proximodistal patterning mechanisms in entirely non-homologous bilaterian appendages (Lemons et al., 2010).”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Lemons et al., 2010
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References 40 · Cited by 45
- Authors
- Lemons, D., Fritzenwanker, J. H., Gerhart, J., Lowe, C. J., & McGinnis, W.
- Affiliations
- University of California San Diego (US)
- University of Chicago (US)
- University of California, Berkeley (US)
- Corresponding author
- McGinnis, William
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 344
- Issue
- 1
- Pages
- 358-362
- ISSN
- 0012-1606 (ISSN-L)
- PMC
- PMC2909331
- OpenAlex
- W1991825130
- Cited by
- 45
- References
- 40
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 2 · 2012: 4
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH grant (R37HD28315, T32GM007240, HD42724)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- co-option, appendage patterning, proximodistal axis, limb development, bilaterian evolution, Drosophila melanogaster, Saccoglossus kowalevskii, hemichordates, neurectoderm, gene expression, evolutionary developmental biology
- MeSH terms
- Animals, Drosophila melanogaster, Biological Evolution, Extremities, Models, Biological, Molecular Sequence Data, Oligonucleotides, Developmental Biology, Genes, Insect, In Situ Hybridization, Gene Expression Regulation, Developmental, Body Patterning, Chordata, Neural Plate
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