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Cited by 23Zebrafish Biomedical Research Applicationsmelanin and skin pigmentationDevelopmental Biology and Gene Regulation

Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes

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Eom, Dae Seok, Patterson, Larissa B., Bostic, Raegan R., Parichy, David M.·2021·Developmental Biology
DOI 10.1016/j.ydbio.2021.04.007PMC PMC10069301

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Abstract

Adhesive interactions are essential for tissue patterning and morphogenesis yet difficult to study owing to functional redundancies across genes and gene families. A useful system in which to dissect roles for cell adhesion and adhesion-dependent signaling is the pattern formed by pigment cells in skin of adult zebrafish, in which stripes represent the arrangement of neural crest derived melanophores, cells homologous to melanocytes. In a forward genetic screen for adult pattern defects, we isolated the pissarro (psr) mutant, having a variegated phenotype of spots, as well as defects in adult fin and lens. We show that psr corresponds to junctional adhesion protein 3b (jam3b) encoding a zebrafish orthologue of the two immunoglobulin-like domain receptor JAM3 (JAM-C), known for roles in adhesion and signaling in other developing tissues, and for promoting metastatic behavior of human and murine melanoma cells. We found that zebrafish jam3b is expressed post-embryonically in a variety of cells including melanophores, and that jam3b mutants have defects in melanophore survival. Jam3b supported aggregation of cells in vitro and was required autonomously by melanophores for an adherent phenotype in vivo. Genetic analyses further indicated both overlapping and non-overlapping functions with the related receptor, Immunoglobulin superfamily 11 (Igsf11) and Kit receptor tyrosine kinase. These findings suggest a model for Jam3b function in zebrafish melanophores and hint at the complexity of adhesive interactions underlying pattern formation.

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Authors
Eom, D. S., Patterson, L. B., Bostic, R. R., & Parichy, D. M.
Affiliations
University of Virginia (US)
Corresponding author
  • Eom, Dae Seok
  • Parichy, David M.
ORCID
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2021-08
Volume
476
Pages
314-327
ISSN
0012-1606 (ISSN-L)
DOI
10.1016/j.ydbio.2021.04.007
PMC
PMC10069301
OpenAlex
W3133668541
Cited by
23
References
2
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 2
FWCI
2.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Biology (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institutes of Health (R35 GM122471, T32 GM008136)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
JAM-C, melanophores, pigment pattern formation, cell adhesion, immunoglobulin superfamily receptors, KIT receptor tyrosine kinase, neural crest, melanoma metastasis
MeSH terms
Animals, Carrier Proteins, Immunoglobulins, Melanophores, Metamorphosis, Biological, Morphogenesis, Mutation, Neural Crest, Phenotype, Pigmentation, Zebrafish, Signal Transduction, Cell Adhesion Molecules, Gene Expression, Gene Expression Regulation, Developmental, Body Patterning, Zebrafish Proteins, Junctional Adhesion Molecule C

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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