Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: quantification with immunohistochemical for calcium-binding proteins
Abstract
To investigate whether n-3 polyunsaturated fatty acids (n-3 PUFAs) would promote different morphological changes in the hippocampal formation of rats with epilepsy, we performed an immunocytochemical study using parvalbumin (PV) and calretinin (CR) distribution as a marker. Animals subjected to the experimental model of epilepsy with a single dose of pilocarpine were randomly divided into the following groups: animals with epilepsy treated daily with vehicle (EV) and animals with epilepsy treated daily with 85 mg/kg n-3 PUFAs (EW). Control animals administered saline were also randomly divided into two other groups: animals treated daily with vehicle (CV) and animals treated daily with 85 mg/kg n-3 PUFAs (CW). A larger number of PV-positive neurons were observed in EW when compared with EV, CV, and CW. Similarly, there were significantly more CR-positive neurons in EW than in EV. These findings demonstrate that omega-3 fatty acids prevent status epilepticus-associated neuropathological changes in the hippocampal formation of rats with epilepsy.
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DHA reduces vulnerable interneuronal cell populations, and NPD1 could be the mediator of that neuroprotection.
“Also, our observations support the evidence that DHA reduces those vulnerable interneuronal cell populations and NPD1 could be the mediator of that neuroprotection (Ferrari et al., 2008).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Ferrari et al., 2008
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References 42 · Cited by 70
- Authors
- Ferrari, D., Cysneiros, R. M., Scorza, C. A., Arida, R. M., Cavalheiro, E. A., de Almeida, A.-C. G., & Scorza, F. A.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Scorza, Fulvio A.
- Venue
- Epilepsy & Behavior
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 13
- Issue
- 1
- Pages
- 36-42
- ISSN
- 1525-5050 (ISSN-L)
- OpenAlex
- W2145945334
- Cited by
- 70
- References
- 42
- Citations by year
- 2025: 4 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 2 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsy & Behavior (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- omega-3 fatty acids, epilepsy, status epilepticus, pilocarpine-induced epilepsy, hippocampus, neuroprotection, parvalbumin, calretinin, calcium-binding proteins, neuronal survival
- MeSH terms
- Analysis of Variance, Animals, Brain Injuries, Cell Count, Disease Models, Animal, Epilepsy, Hippocampus, Male, Parvalbumins, Pilocarpine, Scopolamine, Fatty Acids, Omega-3, Rats, Sprague-Dawley, Neuroprotective Agents, Rats, S100 Calcium Binding Protein G, Calbindin 2
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