Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis
Abstract
Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. This article is part of a Special Issue entitled "Status Epilepticus".
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Widespread BBB breakdown has been well documented in a mouse model of status epilepticus.
“For example, the widespread BBB breakdown has been well documented in a mouse model of status epilepticus (209).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [209]
Cites
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
Rigau, V., Morin, M., Rousset, M.-C., de Bock, F., Lebrun, A., Coubes, P., Picot, M.-C., Baldy-Moulinier, M., Bockaert, J., Crespel, A., et al. (2007) · Brain · doi:10.1093/brain/awm118 · Cited by 429 · see citing works
Losartan prevents acquired epilepsy via TGF‐β signaling suppression
Bar‐Klein, G., Cacheaux, L. P., Kamintsky, L., Prager, O., Weissberg, I., Schoknecht, K., Cheng, P., Kim, S. Y., Wood, L., Heinemann, U., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24147 · Cited by 270 · see citing works
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
MMPs in learning and memory and neuropsychiatric disorders
Beroun, A., Mitra, S., Michaluk, P., Pijet, B., Stefaniuk, M., & Kaczmarek, L. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03180-8 · Cited by 207 · see citing works
- Authors
- Gorter, J. A., van Vliet, E. A., & Aronica, E.
- Affiliations
- University of Amsterdam (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Gorter, Jan A.
- Venue
- Epilepsy & Behavior
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 49
- Pages
- 13-16
- ISSN
- 1525-5050 (ISSN-L)
- OpenAlex
- W2151136069
- Cited by
- 194
- References
- 4
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 22 · 2023: 17 · 2022: 15 · 2021: 16 · 2020: 16 · 2019: 30 · 2018: 14 · 2017: 17 · 2016: 17 · 2015: 7
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsy & Behavior (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Funders
- European Union Seventh Framework Programme (602102)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- status epilepticus, blood-brain barrier disruption, neuroinflammation, epileptogenesis
- MeSH terms
- Animals, Blood-Brain Barrier, Humans, Inflammation, Status Epilepticus, Rats, Sprague-Dawley, Rats
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