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Cited by 4Epilepsy research and treatmentTactile and Sensory InteractionsDeep Brain Stimulation and Movement Disorders

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Functional characteristics of the human primary somatosensory cortex: An electrostimulation study

Sun, Fengqiao, Zhang, Guojun, Yu, Tao, Zhang, Xiaohua, Wang, Xueyuan, Yan, Xiaoming, Qiao, Liang, Ma, Kai, Zhang, Xi·2021·Epilepsy & Behavior
DOI 10.1016/j.yebeh.2021.107920
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Abstract

The common knowledge of the functional organization of the human primary somatosensory cortex (S1) had been primarily established by Penfield who electrically stimulated the exposed surface [referred as Brodmann area (BA)1] of S1 under neurosurgical conditions. Nevertheless, the functional information regarding the deep surface (BA 2 and 3) of S1 is poorly understood. We retrospectively analyzed all the clinical manifestations induced by extra-operative cortical electrical stimulation (ES) in 33 patients with medically intractable epilepsy who underwent stereo-electroencephalography (SEEG) monitoring for presurgical assessment. Demographic and clinical data were gathered and evaluated to delineate the determinants of the occurrence of positive responses, types of responses, and size of body regions involved. The stimulation of 244 sites in S1 yielded 198 positive sites (81.1%), most of which were located in the sulcal cortex. In multivariable analyses, no clinical or demographic factors predicted the occurrence of responses or their threshold levels. The size of body region involved in the responses had ordinal association with the stimulated BA sites (p < 0.001). Various types of responses elicited from the S1 were documented and classified, and the predictors of those responses were also assessed. Our analysis revealed the functional characteristics of the entire S1 and proved the multiplicity of functions of S1.

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Sorted by citations

Metadata

Authors
Sun, F., Zhang, G., Yu, T., Zhang, X., Wang, X., Yan, X., Qiao, L., Ma, K., & Zhang, X.
Affiliations
Capital Medical University (CN)
Corresponding author
Zhang, Guojun
ORCID
Venue
Epilepsy & Behavior
Publisher
Elsevier BV
Published
2021-05
Volume
118
Pages
107920
ISSN
1525-5050 (ISSN-L)
DOI
10.1016/j.yebeh.2021.107920
OpenAlex
W3138074418
Cited by
4
References
0
Citations by year
2024: 2 · 2023: 2
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Epilepsy & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
Beijing Natural Science Foundation
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
primary somatosensory cortex, cortical electrical stimulation, stereoelectroencephalography, drug-resistant epilepsy, preoperative assessment, sensory evoked potentials
MeSH terms
Brain Mapping, Electric Stimulation, Electric Stimulation Therapy, Humans, Retrospective Studies, Somatosensory Cortex

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