CoChat
Sign Up
Cited by 28

The DOI matches its Crossref record.

The function of neurofascin155 in oligodendrocytes is regulated by metalloprotease-mediated cleavage and ectodomain shedding

Maier, Olaf, van der Heide, Tiemen, Johnson, Richard, Vries, Hans de, Baron, Wia, Hoekstra, Dick·2006·Experimental Cell Research
DOI 10.1016/j.yexcr.2005.11.014
Open this paper in CoChat — free account

Abstract

Formation of the paranodal axo-glial junction requires the oligodendrocyte-specific 155-kDa isoform of neurofascin (NF155). Here, we report the presence of two peptides in cultured oligodendrocytes, which are recognized by distinct NF155-specific antibodies and correspond to a membrane anchor of 30 kDa and a 125 kDa peptide, which is shed from the cells, indicating that it consists of the NF155 ectodomain. Transfection of OLN-93 cells with NF155 verified that both peptides originate from NF155 cleavage, and we present evidence that metalloproteases mediate NF155 processing. Interestingly, metalloprotease activity is required for NF155 transport into oligodendrocyte processes supporting the functional significance of NF155 cleavage. To further characterize NF155 cleavage and function, we transfected MDCK cells with NF155. Although ectodomain shedding was observed in polarized and non-polarized MDCK cells, surface localization of NF155 was restricted to the lateral membrane of polarized cells consistent with a role in cell-cell adhesion. Aggregation assays performed with OLN-93 cells confirmed that NF155 accelerates cell-cell adhesion in a metalloprotease-dependent manner. The physiological relevance of NF155 processing is corroborated by the presence of NF155 cleavage products in heavy myelin, suggesting a role of NF155 ectodomain shedding for the generation and/or stabilization of the nodal/paranodal architecture.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.yexcr.2005.11.014

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In polarized epithelial cells, transfected Schwann cell proteins are distinctly transported, potentially reflecting the segregation of compact and non-compact myelin components.

    “Similarly, in polarized epithelial cells, transfected Schwann cell proteins are distinctly transported, potentially reflecting the segregation of compact and non-compact myelin components (Minuk and Braun, 1996;Kroepfl and Gardinier, 2001;Maier et al., 2006).”

    From SH3TC2, a protein mutant in Charcot–Marie–Tooth neuropathy, links peripheral nerve myelination to endosomal recycling (2010) · cites this paper as Maier et al., 2006

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 33

  1. Collinson, 1998, Transient expression of neurofascin by oligodendrocytes at the onset of myelinogenesis: implications for mechanisms of axon–glial interaction, Glia, 23, 11, 10.1002/(SICI)1098-1136(199805)23:1<11::AID-GLIA2>3.0.CO;2-7 · DOI
  2. Tait, 2000, An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction, J. Cell Biol., 150, 657, 10.1083/jcb.150.3.657 · DOI
  3. Volkmer, 1992, Structure of the axonal surface recognition molecule neurofascin and its relationship to a neural subgroup of the immunoglobulin superfamily, J. Cell Biol., 118, 149, 10.1083/jcb.118.1.149 · DOI
  4. Charles, 2002, Neurofascin is a glial receptor for the paranodin/Caspr–contactin axonal complex at the axoglial junction, Curr. Biol., 12, 217, 10.1016/S0960-9822(01)00680-7 · DOI
  5. Bhat, 2003, Molecular organization of the axo-glial junctions, Curr. Opin. Neurobiol., 13, 552, 10.1016/j.conb.2003.09.004 · DOI
  6. Mechtersheimer, 2001, Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins, J. Cell Biol., 155, 661, 10.1083/jcb.200101099 · DOI
  7. Naus, 2004, Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death, J. Biol. Chem., 279, 16083, 10.1074/jbc.M400560200 · DOI
  8. Gutwein, 2003, ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles, FASEB J., 17, 292, 10.1096/fj.02-0430fje · DOI
  9. Kalus, 2003, The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1, J. Biol. Chem., 278, 10381, 10.1074/jbc.M208351200 · DOI
  10. Oh, 1999, Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes, J. Neurosci., 19, 8464, 10.1523/JNEUROSCI.19-19-08464.1999 · DOI
  11. Larsen, 2004, The expression of matrix metalloproteinase-12 by oligodendrocytes regulates their maturation and morphological differentiation, J. Neurosci., 24, 7597, 10.1523/JNEUROSCI.2092-04.2004 · DOI · Paper page
  12. Bernstein, 2004, ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes, J. Neurosci. Res., 75, 353, 10.1002/jnr.10858 · DOI
  13. Volkmer, 1998, Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells, J. Cell Biol., 142, 1083, 10.1083/jcb.142.4.1083 · DOI
  14. Gollan, 2003, Caspr regulates the processing of contactin and inhibits its binding to neurofascin, J. Cell Biol., 163, 1213, 10.1083/jcb.200309147 · DOI
  15. Rios, 2000, Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination, J. Neurosci., 20, 8354, 10.1523/JNEUROSCI.20-22-08354.2000 · DOI
  16. Koch, 1997, Expression of the immunoglobulin superfamily cell adhesion molecule F3 by oligodendrocyte-lineage cells, Glia, 19, 199, 10.1002/(SICI)1098-1136(199703)19:3<199::AID-GLIA3>3.0.CO;2-V · DOI
  17. Krämer, 1999, Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination, J. Biol. Chem., 274, 29042, 10.1074/jbc.274.41.29042 · DOI
  18. Maier, 2005, Alteration of the extracellular matrix interferes with raft-association of neurofascin in oligodendrocytes. Potential significance for multiple sclerosis?, Mol. Cell. Neurosci., 28, 390, 10.1016/j.mcn.2004.09.012 · DOI
  19. Richter-Landsberg, 1996, OLN-93: a new permanent oligodendroglia cell line derived from primary rat brain glial cultures, J. Neurosci. Res., 45, 161, 10.1002/(SICI)1097-4547(19960715)45:2<161::AID-JNR8>3.0.CO;2-8 · DOI
  20. Relvas, 2001, Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination, Curr. Biol., 11, 1039, 10.1016/S0960-9822(01)00292-5 · DOI
  21. Hassel, 1997, Organization of the neurofascin gene and analysis of developmentally regulated alternative splicing, J. Biol. Chem., 272, 28742, 10.1074/jbc.272.45.28742 · DOI
  22. de Vries, 2000, On the biogenesis of the myelin sheath: cognate polarized trafficking pathways in oligodendrocytes, Glycoconjugate J., 17, 181, 10.1023/A:1026533021994 · DOI
  23. Zegers, 1998, Mechanisms and functional features of polarized membrane traffic in epithelial and hepatic cells, Biochem. J., 336, 257, 10.1042/bj3360257 · DOI
  24. Peiretti, 2005, Proteasome inhibition activates the transport and the ectodomain shedding of TNF-alpha receptors in human endothelial cells, J. Cell Sci., 118, 1061, 10.1242/jcs.01696 · DOI
  25. Reiss, 2005, ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling, EMBO J., 24, 742, 10.1038/sj.emboj.7600548 · DOI
  26. Hübschmann, 2005, Neural cell adhesion molecule function is regulated by metalloproteinase-mediated ectodomain release, J. Neurosci. Res., 80, 826, 10.1002/jnr.20530 · DOI
  27. Baron, 1998, Regulation of oligodendrocyte differentiation: protein kinase C activation prevents differentiation of O2A progenitor cells toward oligodendrocytes, Glia, 22, 121, 10.1002/(SICI)1098-1136(199802)22:2<121::AID-GLIA3>3.0.CO;2-A · DOI
  28. Lee, 2003, Induction of matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide-stimulated primary astrocytes is mediated by extracellular signal-regulated protein kinase 1/2 (Erk1/2), Glia, 41, 15, 10.1002/glia.10131 · DOI
  29. de Vries, 1998, An apical-type trafficking pathway is present in cultured oligodendrocytes but the sphingolipid-enriched myelin membrane is the target of a basolateral-type pathway, Mol. Biol. Cell, 9, 599, 10.1091/mbc.9.3.599 · DOI
  30. Yang, 1999, Trilinolein potentiates the pro-aggregating effect of phorbol-12-myristate 13-acetate in human polymorphonuclear leukocytes, Int. J. Immunopharmacol., 21, 829, 10.1016/S0192-0561(99)00052-1 · DOI
  31. Takizawa, 1997, Relationships of subunits of type-1 serine/threonine protein phosphatase to morphology and aggregation of B cells, J. Biochem. (Tokyo), 122, 723, 10.1093/oxfordjournals.jbchem.a021815 · DOI
  32. Rosenberg, 2002, Matrix metalloproteinases and neuroinflammation in multiple sclerosis, Neuroscientist, 8, 586, 10.1177/1073858402238517 · DOI
  33. Wolswijk, 2003, Changes in the expression and localization of the paranodal protein Caspr on axons in chronic multiple sclerosis, Brain, 126, 1638, 10.1093/brain/awg151 · DOI

Cited by

Sorted by citations

Metadata

Authors
Maier, O., van der Heide, T., Johnson, R., Vries, H. D., Baron, W., & Hoekstra, D.
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2006-02
Volume
312
Issue
4
Pages
500-511
ISSN
0014-4827
DOI
10.1016/j.yexcr.2005.11.014
Cited by
28
References
0
Language
en
Licence
Funders
Stichting MS Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review