MicroRNA-23a is involved in tumor necrosis factor-α induced apoptosis in mesenchymal stem cells and myocardial infarction
Abstract
Cell therapy has emerged as an attractive therapeutic modality to treat myocardial infarction (MI) via repairing damaged myocardium, and mesenchymal stem cells (MSCs) are an appealing therapeutic approach for cardiac regeneration. However, the clinical application of MSC-based therapy is restricted because of the poor survival of implanted cells, and this poor survival remains poorly understood. Using a tumor necrosis factor (TNF)-α-induced bone marrow (BM)-MSC injury model in vitro and a rat MI model in vivo, we showed in the current study that miR-23a was involved in TNF-α-induced BM-MSC apoptosis through regulating caspase-7 and that the injection of BM-MSCs overexpressing miR-23a could improve left ventricular (LV) function and reduce infarct size in the rat MI model. Our findings elucidate the etiology of MI and provide an alternative treatment strategy for patients with heart failure caused by MI who are not optimal candidates for surgical treatment.
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Overexpression of miR-23a can improve hypoxia/serum deprivation-induced MSC apoptosis and increase their survival rate; downregulation of miR-23 can exacerbate TNF-α-induced MSC apoptosis by regulating caspase-7.
“Overexpression of miR-23a can improve hypoxia/serum deprivation-induced MSC apoptosis and increase their survival rate; conversely, downregulation of miR-23 can exacerbate TNF-α-induced MSC apoptosis by regulating caspase-7 [55,56].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [56]
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References 54 · Cited by 42
- Authors
- Mao, J., Lv, Z., & Zhuang, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Lv, Zhiqian
- ORCID
- Zhuang, Yu
- Venue
- Experimental and Molecular Pathology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 97
- Issue
- 1
- Pages
- 23-30
- ISSN
- 0014-4800 (ISSN-L)
- OpenAlex
- W2036908008
- Cited by
- 42
- References
- 54
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 8 · 2014: 5
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Experimental and Molecular Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Technology Commission of Shanghai Municipality (10411953300)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- miR-23a, microRNA, TNF-α, mesenchymal stem cells, apoptosis, caspase-7, myocardial infarction, bone marrow-derived stem cells, stem cell survival, cell therapy, cardiac regeneration, left ventricular function, infarct size
- MeSH terms
- Animals, Cells, Cultured, Disease Models, Animal, Dose-Response Relationship, Drug, Gene Expression Regulation, Heart Ventricles, Humans, Male, Myocardial Infarction, Tumor Necrosis Factor-alpha, Rats, Sprague-Dawley, Apoptosis, 3' Untranslated Regions, MicroRNAs, Mesenchymal Stem Cell Transplantation, Rats, Caspase 7, HEK293 Cells, Mesenchymal Stem Cells
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