Bisphenol A interferes with synaptic remodeling
Open accessAbstract
The potential adverse effects of Bisphenol A (BPA), a synthetic xenoestrogen, have long been debated. Although standard toxicology tests have revealed no harmful effects, recent research highlighted what was missed so far: BPA-induced alterations in the nervous system. Since 2004, our laboratory has been investigating one of the central effects of BPA, which is interference with gonadal steroid-induced synaptogenesis and the resulting loss of spine synapses. We have shown in both rats and nonhuman primates that BPA completely negates the ∼ 70-100% increase in the number of hippocampal and prefrontal spine synapses induced by both estrogens and androgens. Synaptic loss of this magnitude may have significant consequences, potentially causing cognitive decline, depression, and schizophrenia, to mention those that our laboratory has shown to be associated with synaptic loss. Finally, we discuss why children may particularly be vulnerable to BPA, which represents future direction of research in our laboratory.
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Neonatal treatment with BPA reduces sex differences in the brain and can modify neurite and dendrite formation in rodents.
“Neonatal treatment with BPA in general reduces sex differences in the brain and can modify neurite and dendrite formation [3], [8], [9], [10], [11].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [8]
The section on testosterone-induced synaptogenesis (page unavailable) reports that BPA reduced spine synapses in adult male rats, supporting a narrower claim about altered brain structure. The perinatal-exposure section discusses developmental effects but says data on BPA’s interference with synapse development were lacking. The copy does not establish that neonatal BPA treatment generally reduces brain sex differences or modifies neurite and dendrite formation in rodents. (LLM, conf=0.82)
Experimental — accuracy not yet measuredBPA exposure has been linked to effects in the developing brain, including altered synapse formation and abnormalities in neurite and dendrite morphology.
“However, BPA exposure has also been linked to effects in the developing brain, including altered synapse formation and abnormalities in neurite and dendrite morphology [ 132 ], and it is associated with cognitive and social impairments in rodents [ 48 , 133–135 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [132]
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References 186 · Cited by 101
Research works printed but not linked: 1
- [47]Hajszan T MacLusky NJ Johansen JA Jordan CL Leranth C Effects of androgens and estradiol on spine synapse formation in the prefrontal cortex of normal and testicular feminization mutant male rats Endocrinology 2007 148 1963 1967 17317772 PMC2128740
- Authors
- Hajszan, T., & Leranth, C.
- Affiliations
- Yale University (US)
- Corresponding author
- Leranth, Csaba
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 31
- Issue
- 4
- Pages
- 519-530
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC2964437
- OpenAlex
- W2016527659
- Cited by
- 101
- References
- 186
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 14 · 2013: 13 · 2012: 6
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH074021, MH074021)
- National Institute of Environmental Health Sciences (R01ES017013, R21ES014893, ES014893)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- bisphenol A, xenoestrogens, synaptic remodeling, synaptogenesis, dendritic spine loss, hippocampus, prefrontal cortex, sex steroids, estrogen, androgens, neuroendocrine disruption, cognitive decline, depression, schizophrenia, child vulnerability
- MeSH terms
- Bisphenol A Compounds, Androgens, Animals, Benzhydryl Compounds, Depression, Estrogens, Estrogens, Non-Steroidal, Female, Hippocampus, Humans, Male, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Primates, Synapses, Prefrontal Cortex, Mice, Rats, Neurogenesis
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