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Cited by 46Reproductive biology and impacts on aquatic speciesAnimal Behavior and ReproductionDevelopmental Biology and Gene Regulation

Gene-expression signatures of Atlantic salmon’s plastic life cycle

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Aubin-Horth, Nadia, Letcher, Benjamin H., Hofmann, Hans A.·2009·General and Comparative Endocrinology
DOI 10.1016/j.ygcen.2009.04.021PMC PMC2706306
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Abstract

How genomic expression differs as a function of life history variation is largely unknown. Atlantic salmon exhibits extreme alternative life histories. We defined the gene-expression signatures of wild-caught salmon at two different life stages by comparing the brain expression profiles of mature sneaker males and immature males, and early migrants and late migrants. In addition to life-stage-specific signatures, we discovered a surprisingly large gene set that was differentially regulated-at similar magnitudes, yet in opposite direction-in both life history transitions. We suggest that this co-variation is not a consequence of many independent cellular and molecular switches in the same direction but rather represents the molecular equivalent of a physiological shift orchestrated by one or very few master regulators.

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Authors
Aubin-Horth, N., Letcher, B. H., & Hofmann, H. A.
Affiliations
  • United States Geological Survey (US)
  • The University of Texas at Austin (US)
Corresponding author
Hofmann, Hans A.
ORCID
Venue
General and Comparative Endocrinology
Publisher
Elsevier BV
Published
2009-09
Volume
163
Issue
3
Pages
278-284
ISSN
0016-6480 (ISSN-L)
DOI
10.1016/j.ygcen.2009.04.021
PMC
PMC2706306
OpenAlex
W2100413928
Cited by
46
References
3
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
3.13
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General and Comparative Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Dana-Farber Cancer Institute
  • National Institute of General Medical Sciences (P50GM068763, GM-068763)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
Atlantic salmon, life-history plasticity, gene expression signatures, brain gene expression, sneaker males, immature male, life stage transitions, master regulators
MeSH terms
Animals, Life Cycle Stages, Male, Salmo salar, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling

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