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High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas

Giatromanolaki, Alexandra, Koukourakis, Michael I., Koutsopoulos, Anastasios, Chloropoulou, Pelagia, Liberis, Vasileios, Sivridis, Efthimios·2011·Gynecologic Oncology
DOI 10.1016/j.ygyno.2011.06.023
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Abstract

Objective To investigate the prognostic role of Beclin 1 in endometrial adenocarcinomas of the endometrioid cell type. Beclin 1 is a known tumor suppressor gene, but its function may be altered under conditions of an accelerated autophagic activity, which provides additional energy to proliferating cells by recycling defective organelles and long-lived cytoplasmic proteins. Materials and methods One hundred and fifty-five endometrioid adenocarcinomas were investigated for their autophagic activity using the monoclonal antibody Beclin 1 and an automated immunohistochemical technique. The extent of Beclin 1 expression was evaluated on a three-tier scale as follows: low ( 50% positive tumor cells). The results were correlated with the degree of tumor differentiation, the depth of myometrial invasion and the overall 5-year survival. In addition, the endometrial tumors were immunostained with the hypoxia inducible factor 1α (HIF1α) and their expression was related to Beclin 1. Results A high Beclin 1 reactivity occurred in 18.1% of endometrial adenocarcinomas studied and was associated with high tumor grade, high myometrial invasion and a poor 5-year survival. It was also correlated positively with HIF1α. Of the remaining adenocarcinomas 29.7% were of intermediate Beclin 1 reactivity and 52.2% of low, but correlations with prognostic factors were insignificant. Conclusion An increased Beclin 1 expression is connected with the most aggressive endometrioid adenocarcinomas, probably…

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Metadata

Authors
Giatromanolaki, A., Koukourakis, M. I., Koutsopoulos, A., Chloropoulou, P., Liberis, V., & Sivridis, E.
Venue
Gynecologic Oncology
Publisher
Elsevier BV
Published
2011-10
Volume
123
Issue
1
Pages
147-151
ISSN
0090-8258
DOI
10.1016/j.ygyno.2011.06.023
Cited by
70
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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