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An open-label, phase II basket study of olaparib and durvalumab (MEDIOLA): Results in germline BRCA -mutated ( gBRCA m) platinum-sensitive relapsed (PSR) ovarian cancer (OC)
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“Besides, olaparib and durvalumab arm also had a higher ORR than that reported for PARPi treatment in germline BRCA-mutated platinum-sensitive relapsed ovarian cancer [229].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [229]
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“Olaparib was purchased from ChemScene (Monmouth, NJ, USA) and dissolved in dimethyl sulfoxide (DMSO) (Sigma-Aldrich, St. Louis, MO, USA).”
MethodSelf-citationPARP inhibitors in ovarian cancer: evidence for maintenance and treatment strategies
Bahena-González, A., Toledo‐Leyva, A., & Gallardo‐Rincón, D. (2020) · Chinese Clinical Oncology · doi:10.21037/cco-20-69 · Cited by 7
“Early phase clinical trials testing the combination of PARP inhibitors plus immunotherapy in ovarian cancer patients have showed some promising results (47,48).”
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“There is also interest in the intersection between PARPis and immunotherapy in OC (Maiorano et al. 2022), and the PD-1 inhibitor pembrolizumab (Konstantinopoulos et al. 2019) and PD-L1 inhibitor durvalumab (Drew et al. 2018) have been evaluated combined with PARPi in phase I and/or II trials.”
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Metadata
- Authors
- Drew, Y., de Jonge, M., Hong, S. H., Park, Y. H., Wolfer, A., Brown, J., Ferguson, M., Gore, M. E., Alvarez, R. H., Gresty, C., Angell, H., Meyer, K., Learoyd, M., Tang, M., Lanasa, M., Herbolsheimer, P., & Domchek, S. M.
- Affiliations
- Newcastle University (GB)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Samsung Medical Center (KR)
- Centre Hospitalier Universitaire Vaudois (CH)
- Beatson West of Scotland Cancer Centre (GB)
- NHS Tayside (GB)
- Royal Marsden Hospital (GB)
- AstraZeneca (United Kingdom) (GB)
- AstraZeneca (United States) (US)
- University of Pennsylvania (US)
- Corresponding author
- Drew, Y.
- ORCID
- Venue
- Gynecologic Oncology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 149
- Pages
- 246-247
- ISSN
- 0090-8258 (ISSN-L)
- OpenAlex
- W2811158315
- Cited by
- 131
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 14 · 2022: 12 · 2021: 19 · 2020: 37 · 2019: 30 · 2018: 6
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecologic Oncology (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Keywords
- olaparib, durvalumab, germline BRCA mutation, platinum-sensitive recurrent ovarian cancer, PARP inhibitors, PD-L1 inhibitors, combination therapy, maintenance therapy, treatment efficacy and safety
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