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Cited by 113LGBTQ Health, Identity, and PolicySexual Differentiation and DisordersBone health and osteoporosis research

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Cross-sex pattern of bone mineral density in early onset gender identity disorder

Haraldsen, I.R., Haug, E., Falch, J., Egeland, T., Opjordsmoen, S.·2007·Hormones and Behavior
DOI 10.1016/j.yhbeh.2007.05.012
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Abstract

Hormonally controlled differences in bone mineral density (BMD) between males and females are well studied. The effects of cross-sex hormones on bone metabolism in patients with early onset gender identity disorder (EO-GID), however, are unclear. We examined BMD, total body fat (TBF) and total lean body mass (TLBM) in patients prior to initiation of sex hormone treatment and during treatment at months 3 and 12. The study included 33 EO-GID patients who were approved for sex reassignment and a control group of 122 healthy Norwegians (males, n=77; females, n=45). Male patients (n=12) received an oral dose of 50 mug ethinylestradiol daily for the first 3 months and 100 mug daily thereafter. Female patients (n=21) received 250 mg testosterone enantate intramuscularly every third week. BMD, TBF and TLBM were estimated using dual energy X-ray absorptiometry (DXA). In male patients, the DXA measurements except TBF were significantly lower compared to their same-sex control group at baseline and did not change during treatment. In female patients, the DXA measurements were slightly higher than in same-sex controls at baseline and also remained unchanged during treatment. In conclusion, this study reports that body composition and bone density of EO-GID patients show less pronounced sex differences compared to controls and that bone density was unaffected by cross-sex hormone treatment.

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Crossref · 10.1016/j.yhbeh.2007.05.012

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  1. Lips, 1996, The effect of androgen treatment on bone metabolism in female to male transsexuals, J. Bone Miner. Res., 11

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Metadata

Authors
Haraldsen, I. R., Haug, E., Falch, J., Egeland, T., & Opjordsmoen, S.
Affiliations
  • University of Oslo (NO)
  • Oslo University Hospital (NO)
Corresponding author
Haraldsen, I.R.
ORCID
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2007-09
Volume
52
Issue
3
Pages
334-343
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2007.05.012
OpenAlex
W2049000320
Cited by
113
References
94
Citations by year
2026: 2 · 2025: 8 · 2024: 9 · 2023: 22 · 2022: 9 · 2021: 5 · 2020: 15 · 2019: 11 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Norges Forskningsråd
  • National Institutes of Health
Topics
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
bone mineral density, sex differences, ethinyl estradiol, body composition, total body fat, lean body mass, sex reassignment, bone metabolism
MeSH terms
Adult, Age Factors, Body Composition, Bone and Bones, Ethinyl Estradiol, Female, Follow-Up Studies, Gender Identity, Humans, Male, Middle Aged, Sex Characteristics, Gonadal Steroid Hormones, Testosterone, Transsexualism, Absorptiometry, Photon, Bone Density, Statistics, Nonparametric

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