Frank A. Beach Award: Programming of neuroendocrine function by early-life experience: A critical role for the immune system
Open accessAbstract
Many neuropsychiatric disorders are associated with a strong dysregulation of the immune system, and several have a striking etiology in development as well. Our recent evidence using a rodent model of neonatal Escherichia coli infection has revealed novel insight into the mechanisms underlying cognitive deficits in adulthood, and suggests that the early-life immune history of an individual may be critical to understanding the relative risk of developing later-life mental health disorders in humans. A single neonatal infection programs the function of immune cells within the brain, called microglia, for the life of the rodent such that an adult immune challenge results in exaggerated cytokine production within the brain and associated cognitive deficits. I describe the important role of the immune system, notably microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition.
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In adulthood, a subsequent stressor can lead activated microglia to secrete more pro-inflammatory cytokines.
“Notably, in adulthood, a subsequent stressor can lead these activated microglia to secrete more pro-inflammatory cytokines (Bilbo, 2013).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Bilbo, 2013
Early adversity, including maternal separation and early infection, during infancy results in larger, activated microglia in rodents.
“In particular, rodent studies have demonstrated that early adversity, including maternal separation and early infection, during infancy results in larger, activated microglia, resident immune cells in the brain that secrete inflammatory cytokines (Bilbo, 2013; Gracia-Rubio et al., 2015).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Bilbo, 2013
The developmental trigger determines whether changed priming weakens or strengthens later immune responses.
“Depending on the developmental trigger, altered priming can impair or enhance reactions to subsequent immune challenges224,225.”
From Immune mediators in the brain and peripheral tissues in autism spectrum disorder (2015) · cites this paper as [224]
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References 87 · Cited by 46
- Authors
- Bilbo, S. D.
- Affiliations
- Duke University (US)
- Corresponding author
- Bilbo, Staci D.
- ORCID
- Bilbo, Staci D.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 63
- Issue
- 5
- Pages
- 684-691
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3667966
- OpenAlex
- W2143354026
- Cited by
- 46
- References
- 87
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 4
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01 MH083698)
- National Institute on Drug Abuse (R01 DA025978)
- National Institute of Environmental Health Sciences (P30 ES011961)
- Duke Institute for Brain Sciences, Duke University
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neuroendocrine function, microglia, cognitive impairment, cytokine production, brain development, neuropsychiatric disorders, immune activation, neuroimmune interactions
- MeSH terms
- Animals, Animals, Newborn, Awards and Prizes, Brain, Immune System, Learning, Neurosecretory Systems, Neuroimmunomodulation, Microglia
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