The role of D2 dopamine receptors in oxytocin induced place preference and anxiolytic effect
Open accessAbstract
Neuropeptide oxytocin (OT) is involved in the regulation of social and non-social behaviour. The central nucleus of amygdala (CeA), part of the limbic system, plays an important role in learning, memory, anxiety and reinforcing mechanisms. CeA has been shown to be rich in OT receptors in rodents. Our previous findings indicated that OT in the rat CeA has a dose dependent rewarding and anxiolytic effect. The aim of our present study was to examine in the CeA the possible interaction of OT and D2 dopamine (DA) receptor antagonist Sulpiride on reinforcement in place preference test and on anxiety in elevated plus maze test. Wistar rats were microinjected bilaterally with 10 ng OT. In different group of animals 4 μg D2 DA receptor antagonist was applied. Other animals received D2 DA receptor antagonist 15 min before 10 ng OT treatment or vehicle solution into the CeA. Rats receiving 10 ng OT spent significantly longer time in the treatment quadrant during the test session in conditioned place preference test. Prior treatment with D2 DA receptor antagonist blocked the rewarding effects of OT. Antagonist in itself did not influence the time rats spent in the treatment quadrant. In elevated plus maze test, rats receiving 10 ng OT spent significantly longer time on the open arms. Prior treatment with D2 DA receptor antagonist blocked the effects of OT. Our results show that DA system plays a role in positive reinforcing and anxiolytic effects of OT because D2 DA receptor antagonist can block these actions.
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Co-injection of oxytocin with raclopride and prior raclopride administration prevented oxytocin-induced anxiolytic effects.
“both the co-injection of oxytocin with raclopride (de la Mora et al., 2016) and the previous raclopride administration (Laszlo et al., 2020) prevented the oxytocin-induced anxiolytic effects”
From Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions (2023) · cites this paper as Laszlo et al., 2020
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References 59 · Cited by 18
- Authors
- László, K., Péczely, L., Géczi, F., Kovács, A., Zagoracz, O., Ollmann, T., Kertes, E., Kállai, V., László, B., Berta, B., Karádi, Z., & Lénárd, L.
- Affiliations
- University of Pecs (HU)
- Corresponding author
- László, K.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 124
- Pages
- 104777
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W3027304791
- Cited by
- 18
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Hormones and Behavior (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Funders
- European Commission
- European Social Fund (-16-2016-00004, EFOP-3.6.1, ÚNKP-19-4-PTE-86)
- Innovációs és Technológiai Minisztérium (PTE ÁOK KA-2020-06, PTE ÁOK PD-2018-05)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, dopamine D2 receptor, sulpiride, central amygdala, conditioned place preference, anxiolytic effects, reward, dopaminergic system, elevated plus maze, neuropeptide interactions
- MeSH terms
- Amygdala, Animals, Anxiety, Behavior, Animal, Conditioning, Classical, Fear, Male, Oxytocin, Reinforcement, Psychology, Reward, Spatial Behavior, Sulpiride, Anti-Anxiety Agents, Rats, Wistar, Receptors, Dopamine D1, Receptors, Dopamine D2, Receptors, Oxytocin, Maze Learning, Freezing Reaction, Cataleptic, Rats, Dopamine D2 Receptor Antagonists
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