The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
Open accessAbstract
Stem cells play an important role in restoring cardiac function in the damaged heart. In order to mediate repair, stem cells need to replace injured tissue by differentiating into specialized cardiac cell lineages and/or manipulating the cell and molecular mechanisms governing repair. Despite early reports describing engraftment and successful regeneration of cardiac tissue in animal models of heart failure, these events appear to be infrequent and yield too few new cardiomyocytes to account for the degree of improved cardiac function observed. Instead, mounting evidence suggests that stem cell mediated repair takes place via the release of paracrine factors into the surrounding tissue that subsequently direct a number of restorative processes including myocardial protection, neovascularization, cardiac remodeling, and differentiation. The potential for diverse stem cell populations to moderate many of the same processes as well as key paracrine factors and molecular pathways involved in stem cell-mediated cardiac repair will be discussed in this review.
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Cites
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Cited by
Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives
Liang, X., Ding, Y., Zhang, Y., Tse, H.-F., & Lian, Q. (2014) · Cell Transplantation · doi:10.3727/096368913x667709 · Cited by 909
Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
Lai, R. C., Chen, T. S., & Lim, S. K. (2011) · Regenerative Medicine · doi:10.2217/rme.11.35 · Cited by 553
Introduction to Stem Cells and Regenerative Medicine
Kolios, G., & Moodley, Y. (2013) · Respiration · doi:10.1159/000345615 · Cited by 555
Paracrine Effect of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Bone Regeneration
Linero, I., & Chaparro, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107001 · Cited by 323
Babenko, V., Silachev, D., Popkov, V., Zorova, L., Pevzner, I., Plotnikov, E., Sukhikh, G., & Zorov, D. (2018) · Molecules · doi:10.3390/molecules23030687 · Cited by 242
Metadata
- Authors
- Mirotsou, M., Jayawardena, T. M., Schmeckpeper, J., Gnecchi, M., & Dzau, V. J.
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 50
- Issue
- 2
- Pages
- 280-289
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2166040185
- Cited by
- 486
- References
- 115
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Mirotsou, M., Jayawardena, T. M., Schmeckpeper, J., Gnecchi, M., & Dzau, V. J. (2011). Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. Journal of Molecular and Cellular Cardiology. https://doi.org/10.1016/j.yjmcc.2010.08.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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