Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation
Wright, J. Fraser, Le, Tannie, Prado, Joseph, Bahr-Davidson, Jennifer, Smith, Peter H., Zhen, Zhu, Sommer, Jurg M., Pierce, Glenn F. +1 more·2005·Molecular Therapy
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- Comprehensive stress study on recombinant adeno-associated virus vectors: Evaluating the capabilities of established analytical techniquesJakob Heckel, Lukas Bongers, David Naylor, Ole Schmidt, Raphael Ruppert, Marco Thomann, Florian Semmelmann, Angie Kirchner, Alexandra H.E. Machado, Markus Haindl et al. · 2026 · Journal of Pharmaceutical Sciences
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- Inverted Quasi‐Spherical Droplets on Polydopamine–TiO2 Substrates for Enhancing Gene DeliverySeung‐Hyun Kim, Mihyun Lee, Mira Cho, Il‐Sun Kim, Kook In Park, Haeshin Lee, Jae‐Hyung Jang · 2017 · Macromolecular Bioscience
- Expression and purification of the recombinant HBcAg core particles derived from methyltrophic Pichia pastoris, and TEM and AFM of the core particles and their natural aggregatesHong-bao Chen · 2007 · Journal of Electron Microscopy
- Delivery of AAV for Expression of Fluorescent Biosensors in Juvenile Mouse HippocampusCarlos Díaz-García, Nidhi Nathwani, Juan Ramón Martínez‐François, Gary Yellen · 2021 · BIO-PROTOCOL
- Adeno-associated virus serotype 9 structural heterogeneity and stability characterized by charge detection mass spectrometryZachary M. Miller, Li F. Lin, David V. Schaffer, Evan R. Williams · 2025 · Molecular Therapy — Methods & Clinical Development
- Development of an optimized SEC method for characterization of genome DNA leakage from adeno-associated virus productsShuai Li, Xiaoyan Wang, Kuan-Yu Lai, Jonathan Wert, Li Zhi, Mohammed Shameem, Dingjiang Liu · 2024 · Analytical and Bioanalytical Chemistry
- Separation of empty and full adeno-associated viral capsids by MCSGP: From model-based design to implementationLuca Ossi, Helena Marie, Michael Schulte, Mattia Sponchioni · 2025 · Journal of Chromatography A
- Manufacturing Considerations and Challenges for AAV Ocular Gene TherapyGerard A. Rodrigues, Evgenyi Shalaev, Thomas K. Karami, James Cunningham, Hongwen M. Rivers, Shaoxin Feng, Dinen Shah, Nigel K.H. Slater · 2021 · AAPS advances in the pharmaceutical sciences series
- Glycerol facilitates the disaggregation of recombinant adeno-associated virus serotype 2 on mica surfacePeng Wang, Hai Li, Haijun Yang, Hua Bing Wang, Jun Lu, Yi Zhang, Jun Hu · 2007 · Colloids and Surfaces B Biointerfaces
- Optimizing laboratory practices for recombinant adeno-associated viral vectors: impact of stress factors on vector stabilityIrini Skaripa-Koukelli, Ole Schmidt, Christiane Ketterer, Rene Lardenoije, Sarah Qutaishat, Alexandra H.E. Machado, Christoph Dürr, Joost van Haasteren, Pierre Goldbach, Lea Fuchsloch et al. · 2025 · AAPS Open
- A proof of concept study on the use of online two-dimensional SEC-UV-RPLC-MS method for the multi-attribute characterization of gene therapy productsMegane K. Aebischer, Serge L. Rudaz, Davy Guillarme · 2025 · Analytica Chimica Acta
- Efficient AAV9 Purification Using a Single-Step AAV9 Magnetic Affinity Beads IsolationKian Chuan Sia, Zhen Ying Fu, Siti Humairah Mohd Rodhi, Joan Hua Yi Yee, Kun Qu, Shu Uin Gan · 2024 · International Journal of Molecular Sciences
- Suspension Culture Production and Purification of Adeno-Associated Virus by Iodixanol Density Gradient Centrifugation for In Vivo ApplicationsKathryn K. Harris, Oleksandr Kondratov, Sergei Zolotukhin · 2024 · Journal of Visualized Experiments
- A Novel Method for Separating Full and Empty Adeno-Associated Viral Capsids Using UltrafiltrationDeepraj Sarmah, Scott M. Husson · 2024 · Membranes
- Stresses, Stabilization, and Recent Insights in Freezing of BiologicsRui Ming Fang, Pooja Sane, Israel Borges Sebastiao, Bakul S. Bhatnagar · 2023 · AAPS advances in the pharmaceutical sciences series
- A Spatial Interpolation Approach to Assign Magnetic Resonance Imaging-Derived Material Properties for Finite Element Models of Adeno-Associated Virus Infusion Into a Recurrent Brain TumorReed Chen, Julian A. Rey, İbrahim Sacit Tuna, David Tran, Malisa Sarntinoranont · 2024 · Journal of Biomechanical Engineering
- Developing a robust and scalable platform for AAV8 productionAndré Nascimento, Tiago Q. Faria, Tiago Nunes, Joana Gomes Oliveira, José Mendes, António Roldão, Cristina Peixoto · 2025 · Journal of Biotechnology
- Improving Aggregation Control of Recombinant Adeno‐Associated Virus Serotype 2 (rAAV2) With Small Sugars and Ionic SaltsAlexander Burns, Saurav Datta · 2025 · Biotechnology Journal
- Manufacturing of Viral Gene TherapiesG. Anthony Ramirez, Mehdi Gasmi · 2021 · International Ophthalmology Clinics
- Formulation development and feasibility of AAV5 as a lyophilized drug productStephanie K. Vargas, Farrokh Janabi Sharifi, Reinard Nambayan, Saeed Moshashaée, Teruna J. Siahaan · 2025 · Journal of Pharmaceutical Sciences
- Particle Analytics: Comparative Approaches for Analysis of Viral VectorsIrini Skaripa-Koukelli, Aurelia Raducanu, Joost van Haasteren, Juliana Albrecht, Philippe Ringler, Alexandra H.E. Machado · 2023 · Springer eBooks
- Can novel bioreactors improve the cost of goods of viral vectors?Christos Stamatis, Alex Chatel, Suzanne S. Farid · 2023 · Cell and Gene Therapy Insights
- Enrichment of full AAV capsids by preparative strong anion exchange chromatographySuriyasri Subramanian, Marcin Dembek, Nadia Auchus, Alistair R. Hines, Paul W. A. Devine, Åsa Hagner-McWhirter, Jean‐Luc Maloisel, Thomas A. Linke · 2025 · Biotechnology Progress
- Investigation of the colloidal stability of adeno-associated viral vectors and how it influences their chromatographic purificationRosella Prestia, Helena Marie, Michael Schulte, Mattia Sponchioni · 2025 · Separation Science and Technology
- Selectivity for full AAV capsids in affinity capture with camelid ligandsLukas Bongers, Linda Elise Franken, D. K. Hoch, Veronika E. Huber, Veronika Öttl, Elena B. Raaf, Jürgen J. Hubbuch, Roberto Falkenstein, A. Martínez · 2025 · Journal of Chromatography A
- Lyophilization of Adeno-Associated Virus Serotypes for Storage and Global DistributionErin B. McGlinch, Haley E. Mudrick, Christopher H. Evans, Michael A. Barry · 2025 · Biomedicines
- Recent advances for the pharmaceutical production of highly attenuated poxviruses as viral vector platformsLinus G. Weber, Michael Werner Wolff · 2026 · Expert Review of Vaccines
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- DISPERSION AND FIXATION OF ADENO-ASSOCIATED VIRUS WITH GLUTARALDEHYDE FOR AFM STUDIESPENG WANG, Xinyan Wang, Haijun Yang, Junhong Lü · 2008 · Surface Review and Letters
- Phase-Appropriate Potency Assay Development for AAV-Based Gene Therapy ProductsElaine E. Peters, Roland Pach, Shyamtanu Datta · 2023 · Springer eBooks
- Continuous Capture of recombinant AAV Particles Using Twin-Column CaptureSMBJulia M Mueller, Daniela Tobler, Jules Buehler, Damian Hauri, Ralf Plieninger, Sven Göbel, Efe Saygili, Yuki Higuchi, Ryosuke Takahashi, Sebastian Vogg et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- PLGA Depots for Controlled Release of Bevacizumab.Rae Sung Chang · 2016 · Deep Blue (University of Michigan)
- Emerging Gene Therapy Approaches Under Clinical Investigation for Retinal Degenerative DiseasesBenjamin Bakall, Kendra A. Klein, Katrina A Mears · 2020 · Topics in medicinal chemistry
- Mate selection: testing evolutionary hypotheses in a Hong Kong Chinese contextSammy K. Ho · 2004
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- The Tiling Algorithm – A general method for structural characterization of accurate long DNA sequence reads: application to AAV genome sequencesRobert E. Bruccoleri, David Rouleau, Celia Slater, Dimpal Lata, Christopher Phillion, Samuel Adjei, Kiran Adhikari, Serena Dollive · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- An Automated Workflow Leveraging Machine Learning for Physical Titer Determination from Cryo-TEM Images of Adeno-Associated Virus CapsidsLilianna C. Gutierrez, Anne Skaja Robinson · 2025 · Chemical & Biomedical Imaging
- Assessment of Enzyme-Mediated Modulation of rAAV Vectors: Effects on Cellular Transduction and Capsid StabilitySeongkyu Yoon, George Liang · 2026 · Research Square
- Characterization of rAAV vectors packaging in baculovirusinfected insect cellsMagalie Penaud‐Budloo · 2018 · theses.fr (ABES)
- Adeno-Associated Virus Co-Precipitation with Extracellular Vesicles for Genome Editing in Rodent EmbryoPetr Nickl, Maria Barbiera, Jacopo Zini, Tereza Nickl, Aki Ushiki, Michaela Vaškovičová, Jitka Neburková, Vojtech Dolejs, Michaela Šímová, Jana Balounová et al. · 2026 · Research Square
- Combined Plasmid Redesign and Transfection Optimization Significantly Increases Upstream AAV Titers While Maintaining Vector Quality and In Vivo PotencyShiliang Hu, Yinxing Chen, Carmen Wu, Wilhad Hans Reuter, June Deng, Nannan Jia, Noel Walsh, Amy Bastille, Thomas M. Edwards Edwards, Matthias Hebben et al. · 2026 · Microorganisms
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