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A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
Open accessAbstract
The transduction of primary T cells to express chimeric T cell receptors (cTCR) for redirected targeting of tumor cells is an attractive strategy for generating tumor-specific T cells for adoptive therapy. However, tumor cells rarely provide costimulatory signals and hence cTCRs that transmit just a CD3zeta signal can only initiate target cell killing and interferon-gamma release and fail to induce full activation. Although incorporation of a CD28 component results in IL-2 release and limited proliferation, T cell activation remains incomplete. OX40 transmits a potent and prolonged T cell activation signal and is crucial for maintaining an immunological response. We hypothesize that the CD28-OX40-CD3zeta tripartite cytoplasmic domain will provide a full complement of activation, proliferation, and survival signals for enhanced anti-tumor activity.
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Metadata
- Authors
- Pulè, M. A., Straathof, K. C., Dotti, G., Heslop, H. E., Rooney, C. M., & Brenner, M. K.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 12
- Issue
- 5
- Pages
- 933-941
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W1999843922
- Cited by
- 487
- References
- 0
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pulè, M. A., Straathof, K. C., Dotti, G., Heslop, H. E., Rooney, C. M., & Brenner, M. K. (2005). A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2005.04.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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