Burden of disease attributable to second-hand smoke exposure: A systematic review
Open accessAbstract
Our aim was to provide a systematic review of studies on the burden of disease due to second-hand smoke (SHS) exposure, reviewing methods, exposure assessment, diseases causally linked to SHS, health outcomes, and estimates available to date. A literature review of studies on the burden of disease from SHS exposure, available in PubMed and SCOPUS, published 2007-2018 in English language, was carried out following the PRISMA recommendations. Overall, 588 studies were first identified, and 94 were eligible. Seventy-two studies were included in the systematic review. Most of them were based on the comparative risk assessment approach, assessing SHS exposure using mainly surveys on exposure at home/workplaces. Diseases more frequently studied were: lung cancer, ischemic heart disease, stroke, chronic obstructive pulmonary disease, asthma and breast cancer in adults; lower respiratory tract infection, otitis media, asthma, sudden infant death syndrome and low birth weight in children. The SHS exposure assessment and the reported population attributable fractions (PAF) were largely heterogeneous. As an example, the PAF from lung cancer varied between 0.6% and 20.5%. Moreover, PAF were estimated applying relative risks and SHS exposures with no consistent definitions or with different age classes. The research gap on the SHS exposure burden is shrinking. However, estimates are not yet available for a number of countries, particularly the Middle Eastern and African countries, and not…
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Previous research, including meta-analyses, found suggestive evidence of an association between SHS exposure and breast cancer.
“Additionally, previous research, including meta-analyses, found suggestive evidence of an association between SHS exposure and breast cancer13–15.”
From Health effects associated with exposure to secondhand smoke: a Burden of Proof study (2024) · cites this paper as [15]
Cites
Öberg, M., Jaakkola, M. S., Woodward, A., Peruga, A., & Prüss-Ustün, A. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61388-8 · Cited by 1,911 · see citing works
Smoke-free Legislation and Hospitalizations for Acute Coronary Syndrome
Pell, J. P., Haw, S., Cobbe, S., Newby, D. E., Pell, A. C. H., Fischbacher, C., McConnachie, A., Pringle, S., Murdoch, D., Dunn, F., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa0706740 · Cited by 446 · see citing works
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Health effects associated with exposure to secondhand smoke: a Burden of Proof study
Flor, L. S., Anderson, J. A., Ahmad, N., Aravkin, A., Carr, S., Dai, X., Gil, G. F., Hay, S. I., Malloy, M. J., McLaughlin, S. A., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02743-4 · Cited by 167 · see citing works
“…is supported by 51 unique studies 170,220, 313– 361 and 79 observations (Supplementary Table Based on Egger’s regression test, no significant evidence of publication bias was found for the main lung cancer and breast cancer models or the exploratory models (Table 2 and Supplementary Tables 13–15).”
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- Authors
- Carreras, G., Lugo, A., Gallus, S., Cortini, B., Fernández, E., López, M. J., Soriano, J. B., López-Nicolás, A., Semple, S., Gorini, G., Castellano, Y., Fu, M., Ballbè, M., Amalia, B., Tigova, O., Continente, X., Arechavala, T., Henderson, E., Lugo, A., Liu, X., Bosetti, C., Davoli, E., Colombo, P., O'Donnell, R., Dobson, R., Clancy, L., Keogan, S., Byrne, H., Behrakis, P., Tzortzi, A., Vardavas, C., Vyzikidou, V. K., Bakellas, G., Mattiampa, G., Boffi, R., Ruprecht, A., De Marco, C., Borgini, A., Veronese, C., Bertoldi, M., Tittarelli, A., Verdi, S., Chellini, E., Trapero-Bertran, M., Guerrero, D. C., Radu-Loghin, C., Nguyen, D., Starchenko, P., Ancochea, J., Alonso, T., Pastor, M. T., Erro, M., Roca, A., & Pérez, P.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Hospital Universitario de La Princesa (ES)
- University of Stirling (GB)
- Agencia de Salud Pública de Barcelona (ES)
- Corresponding author
- Carreras, Giulia
- ORCID
- Carreras, Giulia
- Gallus, Silvano
- Fernández, Esteve
- Soriano, Joan B.
- Semple, Sean
- Gorini, Giuseppe
- Castellano, Yolanda
- Fu, Marcela
- Ballbè, Montse
- Amalia, Beladenta
- Tigova, Olena
- Continente, Xavier
- Henderson, Elisabet
- Liu, Xiaoqiu
- Bosetti, Cristina
- Davoli, Enrico
- Dobson, Ruaraidh
- Clancy, Luke
- Keogan, Sheila
- Tzortzi, Anna
- Vardavas, Constantine
- Boffi, Roberto
- Borgini, Alessandro
- Veronese, Chiara
- Tittarelli, Andrea
- Radu-Loghin, Cornel
- Ancochea, Julio
- Alonso, Tamara
- Venue
- Preventive Medicine
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 129
- Pages
- 105833
- ISSN
- 0091-7435 (ISSN-L)
- OpenAlex
- W2971669942
- Cited by
- 158
- References
- 2
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 27 · 2023: 23 · 2022: 22 · 2021: 25 · 2020: 20
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Preventive Medicine (publishedVersion)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion, other-oa)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by-nc-nd)
- Stirling Online Research Repository (University of Stirling) (submittedVersion, cc-by-nc-nd)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion)
- Funders
- Generalitat de Catalunya
- Instituto de Salud Carlos III
- Associazione Italiana per la Ricerca sul Cancro
- Horizon 2020
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- passive smoking, disease burden, population attributable fraction, comparative risk assessment, lung cancer, ischemic heart disease, stroke, chronic obstructive pulmonary disease, asthma, breast cancer, sudden infant death syndrome, low birth weight, otitis media, lower respiratory tract infection, exposure assessment
- MeSH terms
- Chronic Disease, Humans, Tobacco Smoke Pollution, Cost of Illness, Risk Assessment
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