The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review
Open accessAbstract
Silver is used in different applications that result in contact with skin and mucosal surfaces (e.g., jewelry, wound dressings, or eye drops). Intact skin poses an effective barrier against the absorption of silver. Mucosal surfaces are observed to be less effective barriers and compromised skin is often a poor barrier. Silver can deposit as particles in the human body causing a blue-gray discoloration known as argyria. Urine and feces are reported pathways of excretion. Acute human mortality has been observed following an abortion procedure involving the intrauterine administration of 7 g silver nitrate (64 mg silver/kg body weight). Localized argyria has been reported with exposure to silver ions, metallic surfaces, and nanocrystalline silver. Generalized argyria was observed with ionic and nanocrystalline silver in humans at cumulative doses in the range of 70-1500 mg silver/kg body weight. Silver is observed to have a low potential for skin irritation. Eye irritation and some cases of allergic contact dermatitis have been reported. Silver may cause genotoxicity, but additional data are required to assess its carcinogenic potential. Other reported toxicities include hepatic, renal, neurological, and hematological effects.
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Cites
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
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Controlled Release of Biologically Active Silver from Nanosilver Surfaces
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Oral toxicity of silver ions, silver nanoparticles and colloidal silver – A review
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Self-citationEvaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro
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Cited by
Althobaiti, N. A. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115212 · Cited by 64
Gorel, O., Hamuda, M., Feldman, I., & Kucyn‐Gabovich, I. (2024) · Health Science Reports · doi:10.1002/hsr2.1816 · Cited by 18
Metadata
- Authors
- Hadrup, N., Sharma, A. K., & Loeschner, K.
- Venue
- Regulatory Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 98
- Pages
- 257-267
- ISSN
- 0273-2300 (ISSN-L)
- OpenAlex
- W2886359989
- Cited by
- 348
- References
- 45
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Hadrup, N., Sharma, A. K., & Loeschner, K. (2018). Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2018.08.007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
