The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials
Open accessAbstract
In 2008, a proposal for assessing the risk of induction of skin sensitization to fragrance materials Quantitative Risk Assessment 1 (QRA1) was published. This was implemented for setting maximum limits for fragrance materials in consumer products. However, there was no formal validation or empirical verification after implementation. Additionally, concerns remained that QRA1 did not incorporate aggregate exposure from multiple product use and included assumptions, e.g. safety assessment factors (SAFs), that had not been critically reviewed. Accordingly, a review was undertaken, including detailed re-evaluation of each SAF together with development of an approach for estimating aggregate exposure of the skin to a potential fragrance allergen. This revision of QRA1, termed QRA2, provides an improved method for establishing safe levels for sensitizing fragrance materials in multiple products to limit the risk of induction of contact allergy. The use of alternative non-animal methods is not within the scope of this paper. Ultimately, only longitudinal clinical studies can verify the utility of QRA2 as a tool for the prevention of contact allergy to fragrance materials.
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Safford, B., Api, A. M., Barratt, C., Comiskey, D., Daly, E. J., Ellis, G., McNamara, C., O’Mahony, C., Robison, S., Smith, B., et al. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.05.017 · Cited by 1,941
Self-citationNovel database for exposure to fragrance ingredients in cosmetics and personal care products
Comiskey, D., Api, A. M., Barratt, C., Daly, E. J., Ellis, G., McNamara, C., O’Mahony, C., Robison, S. H., Safford, B., Smith, B., et al. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.05.012 · Cited by 1,883
Self-citationSafford, B., Api, A. M., Barratt, C., Comiskey, D., Ellis, G., McNamara, C., O'Mahony, C., Robison, S., Rose, J., Smith, B., et al. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.02.021 · Cited by 1,865
Self-citationComiskey, D., Api, A. M., Barrett, C., Ellis, G., McNamara, C., O'Mahony, C., Robison, S. H., Rose, J., Safford, B., Smith, B., et al. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.05.017 · Cited by 1,840
Self-citationThe Dermal Sensitisation Threshold—A TTC approach for allergic contact dermatitis
Safford, R. J. (2008) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2008.02.010 · Cited by 476
Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework
(2011) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2011.03.010 · Cited by 358
Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients
Api, A. M., Basketter, D. A., Cadby, P. A., Cano, M.-F., Ellis, G., Gerberick, G. F., Griem, P., McNamee, P. M., Ryan, C. A., & Safford, R. (2008) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2007.10.008 · Cited by 336
Self-citationThe Identification of Contact Allergens by Human Assay
Kligman, A. M. (1966) · Journal of Investigative Dermatology · doi:10.1038/jid.1966.159 · Cited by 312
Non-animal methods to predict skin sensitization (II): an assessment of defined approaches
Kleinstreuer, N. C., Hoffmann, S., Alépée, N., Allen, D., Ashikaga, T., Casey, W., Clouet, E., Cluzel, M., Desprez, B., Gellatly, N., et al. (2018) · Critical Reviews in Toxicology · doi:10.1080/10408444.2018.1429386 · Cited by 207
Self-citation(PPR), E. P. O. P. P. P. A. T. R. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2839 · Cited by 199
Metadata
- Authors
- Api, A. M., Basketter, D., Bridges, J., Cadby, P., Ellis, G., Gilmour, N., Greim, H., Griem, P., Kern, P., Khaiat, A., O'Brien, J., Rustemeyer, T., Ryan, C., Safford, B., Smith, B., Vey, M., & White, I. R.
- Venue
- Regulatory Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 118
- Pages
- 104805
- ISSN
- 0273-2300 (ISSN-L)
- OpenAlex
- W3093143378
- Cited by
- 304
- References
- 43
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Api, A. M., Basketter, D., Bridges, J., Cadby, P., Ellis, G., Gilmour, N., Greim, H., Griem, P., Kern, P., Khaiat, A., O'Brien, J., Rustemeyer, T., Ryan, C., Safford, B., Smith, B., Vey, M., & White, I. R. (2020). Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2020.104805
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
