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Cited by 260

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease

Open access
Stein, Bruce C., Levin, Richard I.·1998·American Heart Journal

Abstract

BACKGROUND: The natriuretic peptide family consists of four molecules that share significant amino acid sequence homologic characteristics and a looped motif. Atrial natriuretic peptide and brain natriuretic peptide are similar in their ability to promote natriuresis and diuresis, inhibit the renin-angiotensin-aldosterone axis, and act as vasodilators. Understanding of the actions of C-type natriuretic peptide and dendroaspis natriuretic peptide is incomplete, but these two new family members also act as vasodilators. Because of the rapid evolution of information about this peptide family, we reviewed the state of the art with respect to risk stratification and therapeutic ability. METHODS: English-language papers were identified by a MEDLINE database search covering 1966 through 1997 and supplemented with bibliographic references and texts. CONCLUSIONS: The natriuretic peptides are counterregulatory hormones with prognostically important levels. They are similarly upregulated in heart failure and counteract neurohormones that induce vasoconstriction and fluid retention. BNP may be the superior prognosticator for risk stratification after myocardial infarction and is independent of left ventricular ejection fraction. Lastly, experimental trials suggest that administration of exogenous natriuretic peptides or inhibitors of their catabolism to patients with ischemic heart disease may be clinically beneficial.

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Metadata

Authors
Stein, B. C., & Levin, R. I.
Venue
American Heart Journal
Publisher
Elsevier BV
Published
1998-05
Volume
135
Issue
5
Pages
914-923
ISSN
0002-8703 (ISSN-L)
OpenAlex
W2058493401
Cited by
260
References
41
FWCI
10.89
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease. https://app.cochat.ai/papers/10.1016/s0002-8703(98)70054-7
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Stein, B. C., & Levin, R. I. (1998). Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease. American Heart Journal. https://doi.org/10.1016/s0002-8703(98)70054-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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