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Cited by 129Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men

Austin, Melissa A, Rodriguez, Beatriz L, McKnight, Barbara, McNeely, Marguerite J, Edwards, Karen L, Curb, J.David, Sharp, Dan S·2000·The American Journal of Cardiology
DOI 10.1016/s0002-9149(00)00956-5
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Abstract

Decreased low-density lipoprotein (LDL) particle size is associated with coronary heart disease (CHD) risk among middle-aged Caucasian populations, and has been consistently correlated with increased plasma levels of triglyceride and decreased levels of high-density lipoprotein (HDL) cholesterol. This study examines whether these risk factors predict CHD among older Japanese-American men. With use of the Honolulu Heart Program Lipoprotein Exam 3 (1980 to 1982) as baseline, and 12-year follow-up for CHD events, a nested, case-control study was designed. One hundred forty-five incident CHD cases were identified and matched to 2 controls each. LDL particle diameter (size) was determined by gradient gel electrophoresis. A 10-angstrom (A) decrease in LDL size at baseline was associated with increased risk of incident CHD (relative risk 1.28, 95% confidence interval 1.01 to 1.63). After adjustment for baseline risk factors, the LDL size association was no longer statistically significant (relative risk 1.13, 95% confidence interval 0.86 to 1.49). When principal components analysis was used to define a composite variable for LDL size, triglycerides, and HDL cholesterol, this component predicted CHD independent of smoking, alcohol consumption, physical activity, body mass index, hypertension, diabetes, and beta-blocker use (p <0.01). Therefore, this prospective analysis of data from older, Japanese-American men demonstrated that decreased LDL size is a univariate predictor of incident CHD, and that a composite risk factor of LDL size, triglyceride, and HDL cholesterol was a risk factor for CHD independent of other risk factors.

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Crossref · 10.1016/s0002-9149(00)00956-5

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  1. Austin, 1999, LDL particle size is a risk factor for coronary heart disease independent of triglyceride and HDL cholesterol, Circulation, 99, 1124

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Metadata

Authors
Austin, M. A., Rodriguez, B. L., McKnight, B., McNeely, M. J., Edwards, K. L., Curb, J. D., & Sharp, D. S.
Affiliations
  • University of Washington (US)
  • University of Hawaiʻi at Mānoa (US)
  • National Institutes of Health (US)
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2000-08
Volume
86
Issue
4
Pages
412-416
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(00)00956-5
OpenAlex
W1975051427
Cited by
129
References
31
Citations by year
2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
7.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl050268-09)
  • National Heart, Lung, and Blood Institute (R01 HL50268)
  • National Cancer Institute (R01CA149051)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
triglycerides, HDL cholesterol, coronary artery disease, cardiovascular risk factors, Japanese-American men, older men, Honolulu Heart Program, incident coronary heart disease, lipoprotein metabolism
MeSH terms
Aged, Asian, Coronary Disease, Hawaii, Humans, Japan, Cholesterol, HDL, Lipoproteins, LDL, Male, Middle Aged, Particle Size, Prospective Studies, Risk Factors, Smoking, Triglycerides, Logistic Models, Case-Control Studies, Electrophoresis, Gel, Pulsed-Field

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