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Cited by 140Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Coronary flow reserve and myocardial diastolic dysfunction in arterial hypertension

Galderisi, Maurizio, Cicala, Silvana, Caso, Pio, De Simone, Luigi, D’Errico, Arcangelo, Petrocelli, Antonio, de Divitiis, Oreste·2002·The American Journal of Cardiology
DOI 10.1016/s0002-9149(02)02708-x
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Abstract

The aim of this study was to assess the relation between coronary blood flow and left ventricular (LV) myocardial diastolic dysfunction in arterial hypertension. The study population included 30 hypertensive patients who were free of coronary artery disease and pharmacologic therapies. They underwent standard Doppler echocardiography and color tissue Doppler of the middle posterior septum at baseline and with high-dose dobutamine, and second-harmonic Doppler flow analysis of the distal left anterior descending coronary artery at baseline and after vasodilation by dipyridamole (0.56 mg/kg IV in 4'). Coronary flow reserve (CFR) was estimated as the ratio of hyperemic and baseline diastolic flow velocities. According to CFR, hypertensives were divided into 2 groups: 15 patients with normal CFR (>/=2) and 15 patients with reduced CFR (<2). The 2 groups were comparable for sex, age, body mass index, baseline heart rate, and blood pressure. LV mass index was greater in hypertensives with reduced CFR (p <0.01). By color tissue Doppler, baseline and high-dose dobutamine septal systolic velocities did not differ between the 2 groups. The ratio between myocardial velocities in early diastole and at atrial contraction (E(m)/A(m) ratio) was lower in patients with reduced CFR, both at baseline (p <0.05) and with high-dose dobutamine (p <0.00001). After adjusting for age, body mass index, LV mass index, and both high-dose dobutamine diastolic blood rate and heart rate by a multiple linear regression analysis, E(m)/A(m) ratio at high-dose dobutamine was independently associated with CFR in the overall population (beta 0.62, p <0.0005) (cumulative R(2) 0.38, p <0.0005). In conclusion, this study provides evidence of an independent association between CFR and myocardial diastolic function. In hypertensive patients without coronary artery stenosis, CFR alteration may be a determinant of myocardial diastolic dysfunction or diastolic impairment that should be taken into account as possibly contributing to coronary flow reduction.

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Crossref · 10.1016/s0002-9149(02)02708-x

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Metadata

Authors
Galderisi, M., Cicala, S., Caso, P., De Simone, L., D’Errico, A., Petrocelli, A., & de Divitiis, O.
Affiliations
  • Federico II University Hospital (IT)
  • University of Campania "Luigi Vanvitelli" (IT)
  • Ospedale Monaldi (IT)
Corresponding author
Galderisi, Maurizio
ORCID
Galderisi, Maurizio
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2002-10
Volume
90
Issue
8
Pages
860-864
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(02)02708-x
OpenAlex
W2083752631
Cited by
140
References
32
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 11
FWCI
4.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
coronary flow reserve, hypertension, left ventricular diastolic function, dipyridamole, dobutamine, E/A ratio, left ventricular mass, coronary microvascular dysfunction
MeSH terms
Adult, Blood Flow Velocity, Cardiac Volume, Coronary Circulation, Diastole, Dose-Response Relationship, Drug, Female, Humans, Hypertension, Male, Middle Aged, Myocardial Contraction, Reference Values, Regional Blood Flow, Echocardiography, Doppler, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Echocardiography, Doppler, Color, Echocardiography, Stress

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