Relation of duration of morbid obesity to left ventricular mass, systolic function, and diastolic filling, and effect of weight loss
Abstract
Longer duration of morbid obesity is associated with higher LV mass, poorer LV systolic function, and greater impairment of LV diastolic filling. Weight loss-induced decreases in LV mass and improvements in LV systolic function and diastolic filling are due in part to favorable alterations in LV loading conditions.
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In human studies, conclusions are not firm regarding the direct role of obesity in the development of heart failure.
“However, in human studies, we mainly have to rely on cross-sectional data at this time, and the conclusions are not firm regarding the direct role of obesity in the development of heart failure (14, 46, 132, 376).”
From Cardiac remodeling in obesity (2008) · cites this paper as [14]
Weight loss achieved via life-style modifications or through bariatric surgery have both been consistently associated with reductions in LV dimensions, LV wall thickness, LV mass, and LA dimension.
“Weight loss achieved via life-style modifications or through bariatric surgery have both been consistently associated with reductions in LV dimensions, LV wall thickness, LV mass, and LA dimension (14, 16, 17, 169).”
From Cardiac remodeling in obesity (2008) · cites this paper as [14]
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References 15 · Cited by 292
- Authors
- Alpert, M. A., Lambert, C. R., Panayiotou, H., Terry, B. E., Cohen, M. V., Massey, C. V., Hashimi, M. W., & Mukerji, V.
- Affiliations
- University of South Alabama Medical Center (US)
- University of Missouri (US)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 76
- Issue
- 16
- Pages
- 1194-1197
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2043899578
- Cited by
- 292
- References
- 15
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 12 · 2020: 14 · 2019: 14 · 2018: 4 · 2017: 15 · 2016: 19 · 2015: 14 · 2014: 16 · 2013: 10 · 2012: 14
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- morbid obesity, obesity duration, left ventricular mass, left ventricular systolic function, diastolic filling, weight loss, obesity cardiomyopathy
- MeSH terms
- Adult, Blood Pressure, Diastole, Echocardiography, Female, Heart Ventricles, Humans, Male, Myocardial Contraction, Obesity, Morbid, Time Factors, Weight Loss, Ventricular Function, Left
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