Simultaneous fetal and maternal cotinine levels in pregnant women smokers
Open accessAbstract
OBJECTIVE: Our purpose was to determine the simultaneous concentrations of serum cotinine in both fetal and maternal blood. STUDY DESIGN: Serum cotinine levels were measured in 11 maternal-fetal pairs at percutaneous umbilical blood sampling. Statistical analysis was performed by means of a one-group t test to determine whether the ratio of fetal-to-maternal cotinine was significantly different from 1. RESULTS: Fetal cotinine levels ranged from 75% to 110% of maternal values (mean ratio 0.90, 95% confidence interval 0.83 to 0.97). Fetal levels were significantly lower than maternal concentrations (p = 0.02). CONCLUSIONS: Cotinine, a metabolite of nicotine used to quantify exposure to tobacco smoke, readily gains access to the fetal circulation. Fetal cotinine concentrations in pregnant women smokers are, on average, 90% of maternal values throughout gestation.
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Cotinine is readily passed from mother to infant, with fetal concentrations reaching approximately 90% of maternal values.
“and is readily passed from mother to infant, with fetal concentrations reaching approximately 90% of maternal values.20”
From Maternal Smoking during Pregnancy and Newborn Neurobehavior: Effects at 10 to 27 Days (2009) · cites this paper as [20]
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References 7 · Cited by 55
- Authors
- Donnenfeld, Pulkkinen, A., Palomaki, G. E., Knight, G. J., & Haddow, J. E.
- Affiliations
- Pennsylvania Hospital (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1993-03
- Volume
- 168
- Issue
- 3
- Pages
- 781-782
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2137178799
- Cited by
- 55
- References
- 7
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2020: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- cotinine, cordocentesis, maternal smoking, tobacco smoke exposure, fetal circulation, pregnancy, nicotine metabolites
- MeSH terms
- Cotinine, Female, Fetal Blood, Gestational Age, Humans, Pregnancy, Smoking
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