The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Metabolic effects of progesterone
Abstract
Progesterone has important effects on carbohydrate, lipid and protein metabolism. This steroid induces hyperinsulinemia, possibly by direct action on pancreatic islets, while promoting glycogen storage in the liver. Paradoxically, it antagonizes the effects of insulin on glucose metabolism in adipose tissue and skeletal muscle. Progesterone stimulates deposition of body fat but had catabolic effects on protein metabolism. Provisional evidence is offered that the steroid may influence ketone body production by the liver as well. When these steroid actions are considered together, their most relevant expression appears to be the physiologic changes observed during normal pregnancy.
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“Estrogen, specifically 17β-estradiol, promotes lipolysis and increases fatty acid availability while decreasing the rate of gluconeogenesis with muscle and liver glycogen sparing.”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [156]
In the citing paper
“Robust evidence exists that demonstrates the important roles estrogen and progesterone have in regulating substrate metabolism [20,24,66,70,80,82,84,154–159].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [156]
Citations
Cites
Costrini, N. V., & Kalkhoff, R. K. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106593 · Cited by 287
Self-citationSex Steroid Influence on Hepatic Gluconeogenesis and Glycogen Formation1
Matute, M., & Kalkhoff, R. K. (1973) · Endocrinology · doi:10.1210/endo-92-3-762 · Cited by 173
Self-citationSynthesis of very low density lipoproteins in the cockerel. Effects of estrogen.
Chan, L., Jackson, R. L., O’Malley, B. W., & Means, A. R. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108481 · Cited by 164
Sex steroid influence on triglyceride metabolism.
Kim, H. J., & Kalkhoff, R. K. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108168 · Cited by 154
Self-citationCarbohydrate Metabolism in Pregnancy and the Newborn 1978
Sutherland, H. W., & Stowers, J. M. (1979) · Springer eBooks · doi:10.1007/978-3-642-66972-9 · Cited by 149
THE EFFECTS OF PROGESTERONE ON BODY WEIGHT AND COMPOSITION IN THE RAT
Hervey, E., & Hervey, G. R. (1967) · Journal of Endocrinology · doi:10.1677/joe.0.0370361 · Cited by 133
Progesterone, Pregnancy and the Augmented Plasma Insulin Response1
Kalkhoff, R. K., JACOBSON, M., & LEMPER, D. (1970) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-31-1-24 · Cited by 130
Self-citationOckner, R. K., Lysenko, N., Manning, J. A., Monroe, S. E., & Burnett, D. A. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109753 · Cited by 125
Kalkhoff, R. K., Kissebah, A. H., & Kim, H. J. (1978) · PubMed · Cited by 119
Self-citationHomeostasis During Fasting. II. Hormone Substrate Differences Between Men and Women
Merimee, T. J., & Fineberg, S. E. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-5-698 · Cited by 83
Research works printed but not linked: 1
- McKerns, 1960, The mechanism of action of estrogenic hormones on metabolism, Recent Prog. Horm. Res., 16, 97
Cited by
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Weight Gain During Pregnancy: Reexamining the Guidelines
Rasmussen, K. M., & Yaktine, A. L. (2009) · Cited by 4,052
Oosthuyse, T., & Bosch, A. N. (2010) · Sports Medicine · doi:10.2165/11317090-000000000-00000 · Cited by 380
The endocrine function of human placenta: an overview
Costa, M. A. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.10.005 · Cited by 389
Training-induced alterations of carbohydrate metabolism in women: women respond differently from men
Friedlander, A. L., Casazza, G. A., Horning, M. A., Huie, M. J., Piacentini, M. F., Trimmer, J. K., & Brooks, G. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.1175 · Cited by 216
Kjos, S. L. (1998) · JAMA · doi:10.1001/jama.280.6.533 · Cited by 174
Metadata
- Authors
- Kalkhoff, R. K.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Kalkhoff, Ronald K.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1982-03
- Volume
- 142
- Issue
- 6
- Pages
- 735-738
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2145204429
- Cited by
- 153
- References
- 30
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- progesterone, carbohydrate metabolism, lipid metabolism, protein metabolism, hyperinsulinemia, pancreatic islets, hepatic glycogen storage, insulin resistance, adipose tissue, skeletal muscle, fat deposition, ketone synthesis, pregnancy
- MeSH terms
- Adipose Tissue, Female, Humans, Insulin, Ketone Bodies, Muscles, Pregnancy, Progesterone, Proteins, Carbohydrate Metabolism, Lipid Metabolism
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