Endometriosis—A disease because it is characterized by bleeding
Abstract
The hypothesis is advanced that endometriosis, an ovarian steroid hormone-dependent process, is physiologic unless recurrent bleeding in the ectopic implants causes progressive disease and symptoms. Diagnosis should take into account the detection of chronic bleeding, and efficient medical treatment can be achieved by amenorrhea without the induction of hypoestrogenism.
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All subtypes of endometriosis and adenomyosis go through cyclic or repeated bleeding similar to eutopic endometrium.
“all subtypes as well as adenomyosis have one defining hallmark in common, namely, they all go through cyclic or repeated bleeding similar to eutopic endometrium19.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [19]
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References 24 · Cited by 169
- Authors
- Brosens, I. A.
- Affiliations
- Leuven Institute for Fertility and Embryology (BE)
- Corresponding author
- Brosens, Ivo A.
- ORCID
- Brosens, Ivo A.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 176
- Issue
- 2
- Pages
- 263-267
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1982798184
- Cited by
- 169
- References
- 24
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 14 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, chronic bleeding, ovarian steroids, amenorrhea, estrogen deficiency, medical treatment, disease progression, diagnosis
- MeSH terms
- Endometriosis, Female, Hemorrhage, Humans, Menstruation, Ovarian Cysts, Ovarian Neoplasms, Pelvis, Peritoneal Diseases, Recurrence
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