Selective expression of murine prostate stem cell antigen in fetal and adult tissues and the transgenic adenocarcinoma of the mouse prostate model of prostate carcinogenesis
Open accessAbstract
Prostate stem cell antigen (PSCA) is a GPI-anchored membrane protein whose expression is reportedly up-regulated in a majority of human prostate cancers, including advanced stages and metastases. In this study, we investigate the expression pattern of the murine orthologue of PSCA by in situ hybridization in fetal and adult mouse tissues. Murine PSCA is expressed during fetal development in the urogenital sinus, skin, and gastrointestinal tract. The expression in these tissues is restricted to the most superficial cell layer. In the adult mouse, expression is highest in the mucosal lining of the urinary tract. In the normal adult prostate, expression of PSCA is detected exclusively in the secretory epithelium. Examination of PSCA during carcinogenesis of the murine prostate in the transgenic adenocarcinoma of the mouse prostate model showed a markedly increased expression in areas of neoplasia. The transgenic adenocarcinoma of the mouse prostate model may represent a valuable model for the study of PSCA as a potential target for immunotherapy of prostate cancer, despite potential differences in the pattern of expression between mice and humans.
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Psca expression occurs in the outermost layers of murine skin epithelium during E15-E17.
“Psca expression occurs in the outermost layers of murine skin epithelium during E15–E17.31”
From Single-cell transcriptomics of human-skin-equivalent organoids (2023) · cites this paper as [31]
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Single-cell transcriptomics of human-skin-equivalent organoids
Stabell, A. R., Lee, G. E., Jia, Y., Wong, K. N., Wang, S., Ling, J., Nguyen, S. D., Sen, G. L., Nie, Q., & Atwood, S. X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112511 · Cited by 30 · see citing works
- Authors
- Ross, S., Spencer, S. D., Lasky, L. A., & Koeppen, H.
- Affiliations
- Genentech (US)
- Corresponding author
- Koeppen, Hartmut
- ORCID
- Koeppen, Hartmut
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 158
- Issue
- 3
- Pages
- 809-816
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1850373
- OpenAlex
- W1966702270
- Cited by
- 25
- References
- 0
- Citations by year
- 2023: 1 · 2020: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- prostate stem cell antigen, fetal development, urogenital sinus, prostate carcinogenesis, tissue-specific gene expression
- MeSH terms
- Adenocarcinoma, Animals, Antigens, Neoplasm, Disease Models, Animal, Epithelium, Female, Male, Membrane Glycoproteins, Mice, Transgenic, Neoplasm Proteins, Prostate, Prostatic Neoplasms, RNA, Transcription, Genetic, Urogenital System, In Situ Hybridization, Mice, GPI-Linked Proteins
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