The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human Ligands of the Notch Receptor
Open accessAbstract
During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL. To generate tools for pursuing the role of the Notch pathway in human disease and development, we have cloned and analyzed the expression of three human homologues of the Notch ligands Delta and Serrate, human Jagged1 (HJ1), human Jagged2 (HJ2), and human Delta1 (H-Delta-1), and determined their chromosomal localizations. We have also raised antibodies to HJ1, and used these antibodies in conjunction with in situ hybridization to examine the expression of these ligands in normal and cancerous cervical tissue. We find that, as reported previously for Notch, the ligands are up-regulated in certain neoplastic tissues. This observation is consistent with the notion that Notch signaling is an important element in these pathogenic conditions, raising the possibility that modulation of Notch activity could be used to influence the fate of the cells and offering a conceivable therapeutic avenue.
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Citations
Cites
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068
Cited by
John, G. R., Shankar, S. L., Shafit-Zagardo, B., Massimi, A., Lee, S. C., Raine, C. S., & Brosnan, C. F. (2002) · Nature Medicine · doi:10.1038/nm781 · Cited by 477
Notch1 and Notch2 Have Opposite Effects on Embryonal Brain Tumor Growth
Fan, X., Mikolaenko, I., Elhassan, I., Ni, X., Wang, Y., Ball, D., Brat, D. J., Perry, A., & Eberhart, C. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1446 · Cited by 382
Baladrón, V., Ruiz-Hidalgo, M. J., Nueda, M. L., Díaz-Guerra, M. J. M., García-Ramírez, J. J., Bonvini, E., Gubina, E., & Laborda, J. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.001 · Cited by 226
Talora, C., Sgroi, D. C., Crum, C. P., & Dotto, G. P. (2002) · Genes & Development · doi:10.1101/gad.988902 · Cited by 206
Role of Notch signaling in colorectal cancer
Qiao, L., & Wong, B. C. Y. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp236 · Cited by 154
Metadata
- Authors
- Gray, G. E., Mann, R. S., Mitsiadis, E., Henrique, D., Carcangiu, M.-L., Banks, A., Leiman, J., Ward, D., Ish-Horowitz, D., & Artavanis-Tsakonas, S.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 154
- Issue
- 3
- Pages
- 785-794
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2120656617
- Cited by
- 181
- References
- 1
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gray, G. E., Mann, R. S., Mitsiadis, E., Henrique, D., Carcangiu, M.-L., Banks, A., Leiman, J., Ward, D., Ish-Horowitz, D., & Artavanis-Tsakonas, S. (1999). Human Ligands of the Notch Receptor. The American Journal of Pathology. https://doi.org/10.1016/s0002-9440(10)65325-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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