Regulation of jejunal glucose transporter expression by forskolin
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We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells. The implications of these data for glucose transport are discussed.
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An increase in SGLT-1 protein in the apical brush border of enterocytes occurs in a cAMP-dependent manner in response to basolateral signals, and secondary to increased SGLT-1 transcription and stabilization of the SGLT-1 transcript.
“An increase in SGLT-1 protein in the apical brush border of enterocytes occurs in a cyclic AMP (cAMP)-dependent manner in response to transduction of basolateral signals (54,55), and secondary to an increase in SGLT-1 transcription (56) and stabilization (increased half-life) of the 3 ′ -untranslated region of the SGLT-1 transcript (57,58).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [55]
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References 22 · Cited by 23
Research works printed but not linked: 4
- H. Murer, U. Hopfer, R. Kinne, Adenylate cyclase system in the enterocyte: cellular localization and possible relation to transepithelial transport, in: S. Bon¢ls, P. Fromageot, G. Rosselin (Eds.), First International Symposium on Hormone Receptors in Digestive Tract Physiology. Inserm Symposium No. 3, Elsevier, Amsterdam, 1977, pp. 425^434.
- H. Murer, H. Lucke, R. Kinne, Isolated brush border vesicles as a tool to study disturbances in intestinal solute transport, in: M. Field, J.S. Fordtran, S.G. Schultz (Eds.), Secretory Diarrhea, American Physiological Society, Bethes- da, MD, 1980, pp. 31^43.
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- Authors
- Williams, M., & Sharp, P.
- Affiliations
- University of East Anglia (GB)
- University of Surrey (GB)
- Corresponding author
- Sharp, Paul
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 1559
- Issue
- 2
- Pages
- 179-185
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W1989486604
- Cited by
- 23
- References
- 22
- Citations by year
- 2020: 2 · 2019: 2 · 2018: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- forskolin, SGLT1, GLUT2, glucose transporters, jejunal enterocytes, cyclic AMP, villus, transporter expression regulation, intestinal glucose transport
- MeSH terms
- Cyclic AMP, Animals, Cell Membrane, Colforsin, Gene Expression Regulation, Jejunum, Male, Membrane Glycoproteins, Monosaccharide Transport Proteins, Immunoblotting, Rats, Wistar, Enterocytes, Sodium-Glucose Transporter 1, Glucose Transporter Type 2, Rats
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