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Phosphatidylserine synthase I and II of mammalian cells
Abstract
Phosphatidylserine (PtdSer) in mammalian cells is synthesized through an exchange of free L-serine for the base moiety of pre-existing phospholipids. Studies on PtdSer biosynthesis in Chinese hamster ovary (CHO) cells have suggested that the serine base-exchange is catalyzed by at least two different enzymes; one, named PtdSer synthase I (PSS I), uses phosphatidylcholine (PtdCho) and possibly phosphatidylethanolamine (PtdEtn) as phosphatidyl donors for the serine base-exchange, and the other, named PtdSer synthase II (PSS II), uses PtdEtn but not PtdCho as a phosphatidyl donor. Recently, cDNAs of the PSS I and II have been isolated from CHO-K1 cells. This review will briefly describe the current understanding of PtdSer synthases of mammalian cells, mainly CHO cells.
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In the citing paper
“This screen revealed a requirement for PTDSS1, which encodes an enzyme that produces phosphatidylserine (PS) (13–15).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [13]
In the citing paper
“In contrast to PTDSS1, which exchanges serine for choline, thereby converting PC to PS, PTDSS2 exchanges serine for ethanolamine, thereby converting PE to PS.”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [13]
In the citing paper
“PTDSS1 encodes an enzyme that exchanges serine for choline in phosphatidylcholine (PC), thereby synthesizing PS (13).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [13]
In the citing paper
“Among the highest-scoring genes was PTDSS1, whose product, PS synthase-1, is a major source of PS in cell membranes (13, 14).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [13]
In the citing paper
“PTDSS1, which encodes an enzyme that produces phosphatidylserine (PS) (13–15).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [13]
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Research works printed but not linked: 21
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- Hübscher, 1962, Metabolism of phospholipids VI. The effect of metal ions on the incorporation of l-serine into phosphatidylserine, Biochim. Biophys. Acta, 57, 555, 10.1016/0006-3002(62)91163-0 · DOI
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- Saito, 1996, Immunochemical identification of the pssA gene product as phosphatidylserine synthase I of Chinese hamster ovary cells, FEBS Lett., 395, 262, 10.1016/0014-5793(96)01049-6 · DOI
- Shiao, 1995, Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine, J. Biol. Chem., 279, 11190, 10.1074/jbc.270.19.11190 · DOI
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- Kuge, 1991, A Chinese hamster cDNA encoding a protein essential for phosphatidylserine synthase I activity, J. Biol. Chem., 266, 24184, 10.1016/S0021-9258(18)54410-0 · DOI
- O. Kuge, K. Saito, M. Nishijima, Cloning of a Chinese hamster ovary (CHO) cDNA encoding phosphatidylserine synthase (PSS) II, overexpression of which suppresses the phosphatidylserine biosynthetic defect of a PSS I-lacking mutant of CHO-K1 cells, J. Biol. Chem., 272 (1997) 19133–19139. · DOI
- Kuge, 1986, Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells III. Genetic evidence for utilization of phosphatidylcholine and phosphatidylethanolamine as precursors, J. Biol. Chem., 261, 5795, 10.1016/S0021-9258(17)38452-1 · DOI
- Hasegawa, 1989, Isolation and characterization of a Chinese hamster ovary cell mutant with altered regulation of phosphatidylserine biosynthesis, J. Biol. Chem., 264, 19887, 10.1016/S0021-9258(19)47193-7 · DOI
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- Suzuki, 1985, Purification and properties of an ethanolamine-serine base exchange enzyme of rat brain microsomes, J. Biol. Chem., 260, 1394, 10.1016/S0021-9258(18)89604-1 · DOI
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Self-citation
Metadata
- Authors
- Kuge, O., & Nishijima, M.
- Venue
- Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 1348
- Issue
- 1-2
- Pages
- 151-156
- ISSN
- 0005-2760
- Cited by
- 79
- References
- 0
- Language
- en
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Health Sciences Foundation
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