Cited by 194Posttraumatic Stress Disorder ResearchMigration, Health and TraumaPsychoanalysis and Psychopathology Research

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Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline alone

Otto, Michael W., Hinton, Devon, Korbly, Nicole B., Chea, Andrea, Ba, Phalnarith, Gershuny, Beth S., Pollack, Mark H.·2003·Behaviour Research and Therapy

DOI 10.1016/s0005-7967(03)00032-9

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Abstract

Cambodian refugees with posttraumatic stress disorder (PTSD) represent a cohort in severe need of treatment, but little information is available to guide treatment choices. We selected a sample of pharmacotherapy-refractory individuals to test the efficacy of combination treatment with sertraline and cognitive-behavior therapy (CBT) for treating PTSD. Participants in this pilot study were ten Khmer-speaking women who had been at a mean age of 22-26 years during the Pol Pot period (1975-1979). These patients were randomly assigned to either sertraline alone or combined treatment. We found that combined treatment offered additional benefit in the range of medium to large effect sizes for PTSD and associated symptoms. Our findings indicate that substantial gains can be achieved by adding CBT to pharmacotherapy for PTSD, and that a program of CBT emphasizing information, exposure, and cognitive-restructuring can be successfully modified for Khmer-speaking refugees.

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Authors: Otto, M. W., Hinton, D., Korbly, N. B., Chea, A., Ba, P., Gershuny, B. S., & Pollack, M. H.
Affiliations: Harvard University (US)
North Suffolk Mental Health Association (US)
Corresponding author: Otto, Michael W.
ORCID: Otto, Michael W.
Pollack, Mark H.
Venue: Behaviour Research and Therapy
Publisher: Elsevier BV
Published: 2003-11
Volume: 41
Issue: 11
Pages: 1271-1276
ISSN: 0005-7967 (ISSN-L)
DOI: 10.1016/s0005-7967(03)00032-9
OpenAlex: W2095335279
Cited by: 194
References: 18
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 9 · 2012: 7
FWCI: 12.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behaviour Research and Therapy (publishedVersion)
PubMed (publishedVersion)
Funders: Van Ameringen Foundation
Pfizer Pharmaceuticals
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: post-traumatic stress disorder, sertraline, cognitive behavioral therapy, combination therapy, Cambodian refugees, trauma exposure, cognitive restructuring, culturally tailored interventions
MeSH terms: Adult, Antidepressive Agents, Cambodia, Combined Modality Therapy, Female, Humans, Middle Aged, Pilot Projects, Refugees, Stress Disorders, Post-Traumatic, United States, Cognitive Behavioral Therapy, Sertraline

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Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline alone

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