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Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome
Open accessAbstract
We report the existence of two structurally distinct forms of the angiotensin receptor AT-1 in the mouse. A Balb/c mouse genomic library was screened by homology screening with a polymerase chain reaction (PCR) amplified probe. Restriction mapping and sequencing of the isolated genes revealed the presence of two receptor isoforms, here named the mouse AT-1a and AT-1b receptors, containing 22 different amino acids. Receptor binding studies performed on COS-7 cells transfected with the two receptors revealed that they had similar binding profiles for angiotensin II, angiotensin III and AT-1 or AT-2 specific antagonists. Because many of the structural differences were in the carboxy terminal putative intracellular domain, we speculate that these isoforms may differ in their regulation, signal transduction, or desensitization mechanisms.
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Citations
Cited by
Kobori, H., Nangaku, M., Navar, L. G., & Nishiyama, A. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.3 · Cited by 1,237
Mukoyama, M., Nakajima, M., Horiuchi, M., Sasamura, H., Pratt, R. E., & Dzau, V. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74498-6 · Cited by 768
Self-citationClassical Renin‐Angiotensin System in Kidney Physiology
Sparks, M. A., Crowley, S. D., Gurley, S. B., Mirotsou, M., & Coffman, T. M. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130040 · Cited by 521
Lenkei, Z., Palkovits, M., Corvol, P., & Llorens-Cortès, C. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1997.0155 · Cited by 406
Molecular biology of the renin-angiotensin system.
Griendling, K. K., Murphy, T. J., & Alexander, R. W. (1993) · Circulation · doi:10.1161/01.cir.87.6.1816 · Cited by 400
Metadata
- Authors
- Sasamura, H., Hein, L., Krieger, J. E., Pratt, R. E., Kobilka, B. K., & Dzau, V. J.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 185
- Issue
- 1
- Pages
- 253-259
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2095364526
- Cited by
- 307
- References
- 0
- FWCI
- 18.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sasamura, H., Hein, L., Krieger, J. E., Pratt, R. E., Kobilka, B. K., & Dzau, V. J. (1992). Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/s0006-291x(05)80983-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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