The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Expression of hypoxia-inducible factor 1: mechanisms and consequences
Open accessAbstract
Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays essential roles in mammalian development and physiology. HIF-1 is a heterodimer composed of HIF-1alpha and HIF-1beta subunits. The expression and activity of the HIF-1alpha subunit are tightly regulated by cellular O2 concentration. Under hypoxic conditions, HIF-1 activates the transcription of genes encoding erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase O2 delivery or facilitate metabolic adaptation to hypoxia. HIF-1 is essential for embryonic vascularization and survival, neovascularization in ischemic myocardium, hypoxia-induced pulmonary vascular remodeling, and tumor vascularization. HIF-1alpha is overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. Pharmacologic manipulation of HIF-1 levels may provide a novel therapeutic approach to diseases that represent the most common causes of mortality in Western society, including cancer, chronic lung disease, and myocardial ischemia.
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Cites
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
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Self-citationCellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
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Self-citationDimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
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Self-citationEffects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice
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Cited by
Molecular mechanisms of blood vessel growth
Conway, E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00281-9 · Cited by 1,030
Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Dorpe, J. V., Hellings, P., Gorselink, M., Heymans, S., et al. (2001) · Nature Genetics · doi:10.1038/88842 · Cited by 1,007
VEGF links hippocampal activity with neurogenesis, learning and memory
Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics · doi:10.1038/ng1395 · Cited by 850
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704
Animal response to drastic changes in oxygen availability and physiological oxidative stress
Hermes-Lima, M., & Zenteno-Savı́n, T. (2002) · Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00080-7 · Cited by 587
Metadata
- Authors
- Semenza, G. L.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 59
- Issue
- 1
- Pages
- 47-53
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2077688090
- Cited by
- 511
- References
- 11
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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