The DOI matches its Crossref record; 80 of the 81 references it cites were found in a registry or an index.
The genetics of pediatric-onset bipolar disorder
Abstract
Although bipolar disorder in adults has been extensively studied, early-onset forms of the disorder have received less attention. We review several lines of evidence indicating that pediatric- and early adolescent-onset bipolar disorder cases may prove the most useful for identifying susceptibility genes. Family studies have consistently found a higher rate of bipolar disorder among the relatives of early-onset bipolar disorder patients than in relatives of later-onset cases, which supports the notion of a larger genetic contribution to the early-onset cases. Comorbid pediatric bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) may also define a familial subtype of ADHD or bipolar disorder that is strongly influenced by genetic factors and may, therefore, be useful in molecular genetic studies. There are no twin and adoption studies of pediatric bipolar disorder, but the heritability of this subtype is expected to be high given the results from family studies. Thus, pediatric- and early adolescent-onset bipolar disorder may represent a genetically loaded and homogeneous subtype of bipolar disorder, which, if used in genetic linkage and association studies, should increase power to detect risk loci and alleles.
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“There is evidence to suggest that bipolar disorder consists of multiple distinct subtypes.”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Faraone et al., 2003
In the citing paper
“One measure that appears to stratify some of these subtypes is age at onset (Faraone et al., 2003; Potash et al., 2007).”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Faraone et al., 2003
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Cites
Spitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946
Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577
Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544
Establishment of Diagnostic Validity in Psychiatric Illness: Its Application to Schizophrenia
ROBINS, E., & GUZE, S. B. (1970) · American Journal of Psychiatry · doi:10.1176/ajp.126.7.983 · Cited by 2,243
A genome-wide search for human type 1 diabetes susceptibility genes
Davies, J. L., Kawaguchi, Y., Bennett, S. T., Copeman, J. B., Cordell, H. J., Pritchard, L. E., Reed, P. W., Gough, S. C. L., Jenkins, S. C., Palmer, S. M., et al. (1994) · Nature · doi:10.1038/371130a0 · Cited by 1,276
High rates of schizophrenia in adults with velo-cardio-facial syndrome
Murphy, K. C., Jones, L. A., & Owen, M. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.940 · Cited by 1,024
A Family Study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands
Gershon, E. S. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290100031006 · Cited by 987
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n
Kremer, E., Pritchard, M., Lynch, M., Yu, S., Holman, K., Baker, E., Warren, S., Schlessinger, D., Sutherland, G., & Richards, R. (1991) · Science · doi:10.1126/science.1675488 · Cited by 929
A Familial Alzheimer's Disease Locus on Chromosome 1
Levy‐Lahad, E., Wijsman, E. M., Nemens, E. J., Anderson, L., Goddard, K. A. B., Weber, J. L., Bird, T. D., & Schellenberg, G. D. (1995) · Science · doi:10.1126/science.7638621 · Cited by 832
Mania-Like Symptoms Suggestive of Childhood-Onset Bipolar Disorder in Clinically Referred Children
Wozniak, J. R., Biederman, J., Gouley, K. K., Ablon, J. S., Faraone, S. V., Mundy, E. A., & Mennin, D. S. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199507000-00010 · Cited by 716
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Research works printed but not linked: 1
- Klein, 1998, Resolved, J Am Acad Child Adolesc Psychiatry, 37, 1093
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POSNER, J., RUSSELL, J. A., & PETERSON, B. S. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050340 · Cited by 2,602
CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
Malhotra, D., & Sebat, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.039 · Cited by 854
McClellan, J., Kowatch, R. A., & Findling, R. L. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242240.69678.c4 · Cited by 516
The genetics of bipolar disorder
Barnett, J. H., & Smoller, J. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.080 · Cited by 407
Blader, J. C., & Carlson, G. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.006 · Cited by 355
Metadata
- Authors
- Faraone, S. V., Glatt, S. J., & Tsuang, M. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Faraone, Stephen V
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 53
- Issue
- 11
- Pages
- 970-977
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2056424385
- Cited by
- 151
- References
- 81
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 13
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH 60485, R01MH059624, R01MH43518, R25 MH60485, R01MH057934, R01MH043518, R25MH060485, R13 MH59126, R01 MH 59624, R01MH-57934, R13MH059126)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD37694, R01HD037694)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- early-onset bipolar disorder, susceptibility genes, family studies, heritability, ADHD comorbidity, genetic linkage, genetic association, genetic susceptibility loci
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Child, Child Behavior Disorders, Child, Preschool, Family, Humans, Molecular Biology, Comorbidity, Age of Onset, Age Distribution, Twin Studies as Topic, Genetic Predisposition to Disease
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