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Cited by 703

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Does stress damage the brain?

Open access
Bremner, J.Douglas·1999·Biological Psychiatry
DOI 10.1016/s0006-3223(99)00009-8
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Abstract

Studies in animals showed that stress results in damage to the hippocampus, a brain area involved in learning and memory, with associated memory deficits. The mechanism involves glucocorticoids and possibly serotonin acting through excitatory amino acids to mediate hippocampal atrophy. Patients with posttraumatic stress disorder (PTSD) from Vietnam combat and childhood abuse had deficits on neuropsychological measures that have been validated as probes of hippocampal function. In addition, magnetic resonance imaging (MRI) showed reduction in volume of the hippocampus in both combat veterans and victims of childhood abuse. In combat veterans, hippocampal volume reduction was correlated with deficits in verbal memory on neuropsychological testing. These studies introduce the possibility that experiences in the form of traumatic stressors can have long-term effects on the structure and function of the brain.

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Metadata

Authors
Bremner, J. D.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-04
Volume
45
Issue
7
Pages
797-805
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(99)00009-8
OpenAlex
W2126041442
Cited by
703
References
53
FWCI
10.05
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Does stress damage the brain? https://app.cochat.ai/papers/10.1016/s0006-3223(99)00009-8
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Bremner, J. D. (1999). Does stress damage the brain? Biological Psychiatry. https://doi.org/10.1016/s0006-3223(99)00009-8

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.