Bioelectrorheological model of the cell. VI. Experimental verification of the rheological model of cytoplasmic membrane
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The susceptibility of the Neurospora crassa (slime) cellular membrane to electroporation and electrodestruction in an alternating electric field was further investigated. The results were analyzed according to the dynamic rheological model of the cytoplasmic membrane. Based on an analytical description of membrane susceptibility to electroporation, the rheological parameters of the foregoing process in N. crassa cellular membrane were found: they closely resemble those previously determined for the membranes' destruction. This suggests that both processes are temporally related and are induced within the same structures of the membrane. The dependence of the destruction of the membrane on the time of application and the frequency of the electric field was theoretically predicted and experimentally confirmed.
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The bioelectrorheological model demonstrates the relationship between AEFs, shape deformations, and membrane destabilization, which can contribute to electroporation and other electric field-induced cell phenomena including electrofusion and electro-destruction.
“The bioelectrorheological model of the cell was proposed and has been expanded upon through a series of manuscripts by Pawlowski et al. [40,53,54,55,56,57] (Figure 3B). This model demonstrates the relationship between AEFs, shape deformations, and membrane destabilization, which can contribute to electroporation and other electric field-induced cell phenomena including electrofusion and electro-d”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [56]
Both DC and AC electroporation are believed to cause a dielectric breakdown of the cell; the oscillating nature of AC electroporation is thought to provoke structural fatigue of the membrane, comparable to the extensile stress proposed in the bioelectrorheological model.
“Both types of electroporation are believed to cause a dielectric breakdown of the cell. However, the oscillating nature of AC electroporation is thought to provoke structural fatigue of the membrane [61], comparable to the extensile stress proposed in the bioelectrorheological model [40,53,54,55,56,57].”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [56]
The bioelectrorheological model provides a possible explanation for the causes of electroporation by demonstrating the combined effects of heat energy and extensile stress leading to reversible cell membrane destabilization, which can directly result in electroporation.
“Although the electric field strengths studied by Pawlowski and colleagues [40,53,54,55,56,57] were two orders of magnitude greater than that of TTFields, the bioelectrorheological model provides a possible explanation to the causes of electroporation by demonstrating the combined effects of heat energy and extensile stress leading to reversible cell membrane destabilization, which can directly”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [56]
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References 5 · Cited by 6
- Authors
- Pawlowski, P., Szutowicz, I., Rózycki, S., Zieliński, J., & Fikus, M.
- Affiliations
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 70
- Issue
- 2
- Pages
- 1024-1026
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC1225003
- OpenAlex
- W1964275662
- Cited by
- 6
- References
- 5
- Citations by year
- 2023: 1 · 2021: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- plasma membrane, electroporation, AC electric field, membrane rheology, Neurospora crassa, electric field frequency dependence, membrane damage
- MeSH terms
- Biophysics, Cell Membrane, Electricity, Models, Biological, Neurospora crassa, Rheology, Thermodynamics, Electroporation, Biophysical Phenomena
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