Central α-melanocyte-stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits
Abstract
Intracerebroventricular injection of alpha-melanocyte-stimulating hormone (alpha-MSH) elicited increases in arterial pressure and renal sympathetic nerve activity in conscious rabbits. Pretreatment with intracerebroventricular injection of agouti-related protein, an endogenous melanocortin-3 and 4 receptor antagonist, prevented cardiovascular and sympathetic responses to alpha-MSH. Pretreatment with intracerebroventricular injection of JKC-363, a synthetic specific melanocortin-4 receptor antagonist, also prevented cardiovascular and sympathetic responses to alpha-MSH. In contrast, intravenous alpha-MSH (1 nmol) failed to cause any cardiovascular responses. These results suggest that intracerebroventricularly administered alpha-MSH acts at the melanocortin-4 receptor in the brain and activates sympathetic outflow, resulting in an increase in arterial pressure.
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Acute intracerebroventricular injections of α-MSH increase sympathetic nervous system activity and blood pressure.
“Several previous studies have shown that acute ICV injections of α-MSH increase SNS activity and BP [19, 23, 24].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [23]
The effects of α-MSH on blood pressure are mediated mainly by direct actions on the central nervous system since intravenous injections of α-MSH have no measurable effect on blood pressure.
“The effects of α-MSH on BP are mediated mainly by direct actions on the CNS since i.v. injections of α-MSH have no measureable effect on BP [23, 24].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [23]
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References 25 · Cited by 49
- Authors
- Matsumura, K., Tsuchihashi, T., Abe, I., & Iida, M.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Matsumura, Kiyoshi
- ORCID
- Tsuchihashi, Takuya
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 948
- Issue
- 1-2
- Pages
- 145-148
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1998931842
- Cited by
- 49
- References
- 25
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- alpha-melanocyte-stimulating hormone, melanocortin-4 receptor, sympathetic nervous system, renal sympathetic nerve activity, arterial pressure, agouti-related protein, intracerebroventricular administration, cardiovascular response, melanocortin system
- MeSH terms
- alpha-MSH, Animals, Blood Pressure, Cardiovascular System, Consciousness, Dose-Response Relationship, Drug, Heart Rate, Injections, Intravenous, Injections, Intraventricular, Male, Proteins, Rabbits, Sympathetic Nervous System, Receptors, Corticotropin, Intercellular Signaling Peptides and Proteins, Receptor, Melanocortin, Type 4, Agouti-Related Protein
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