Differential effect of amygdaloid lesions on CRF-41, ACTH and corticosterone responses following neural stimuli
Abstract
The effect of amygdaloid (AMG) lesions on changes in median eminence (ME) CRF-41 and serum ACTH and corticosterone (CS) levels following neural stimuli were investigated in rats. In intact animals photic or acoustic stimuli caused CRF-41 depletion from the ME and a rise in serum ACTH and CS levels. In rats with medial or central AMG nuclei lesions, these responses were blocked. Basal AMG lesions were not effective. Also, all groups of animals responded normally to ether stress. These results indicate a differential effect of AMG nuclei on the hypothalamo-pituitary-adrenocortical (HPA) axis and demonstrate that the facilitatory effect of the AMG nuclei on the HPA axis responses involves the release of ME CRF-41, which stimulates ACTH and consequently CS secretion.
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Lesions to the central and corticomedial groups of the amygdala reduce ACTH and corticosterone secretion following stress.
“Lesions to these groups have been shown to reduce ACTH and corticosterone secretion following stress (66, 67).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [66]
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- Authors
- Feldman, S., Conforti, N., Itzik, A., & Weidenfeld, J.
- Affiliations
- Hadassah Medical Center (IL)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Feldman, Shaul
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 658
- Issue
- 1-2
- Pages
- 21-26
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1978599015
- Cited by
- 153
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 1 · 2012: 10
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- amygdala lesions, ACTH, corticosterone, hypothalamic-pituitary-adrenal axis, median eminence, photic stimulation, auditory stimulation, ether stress, stress response, rats
- MeSH terms
- Acoustic Stimulation, Adrenocorticotropic Hormone, Amygdala, Animals, Corticosterone, Corticotropin-Releasing Hormone, Male, Neural Pathways, Photic Stimulation, Rats
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