The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations
Open accessAbstract
Neuropeptide Y, produced in the arcuate nucleus of the hypothalamus, plays a key role in the central regulation of anterior pituitary and appetitive functions. The pleiotropic nature of neuropeptide Y in these mechanisms indicates the existence of heterogeneity in the hypothalamic neuronal population producing neuropeptide Y. In this study, we report the coexistence of neuropeptide Y and the amino acid transmitter, gamma-aminobutyric acid (GABA), in neuronal perikarya of the arcuate nucleus. Fluorescent double immunolabeling for neuropeptide Y and glutamic acid decarboxylase was carried out on vibratome sections collected through the hypothalamic arcuate nuclei of animals that were pretreated with colchicine. It was found that about one third of the neuropeptide Y-producing arcuate nucleus perikarya co-expressed glutamic acid decarboxylase. This population of neuropeptide Y-containing GABAergic neurons were distributed longitudinally within the arcuate nucleus located predominantly in its dorsomedial aspects. These results show that there are at least two distinct populations of neuropeptide Y-producing neurons in the arcuate nucleus: a subset of neuropeptide Y and GABA-co-producing neurons located in the dorsomedial arcuate nucleus and a subset of non-GABAergic neuropeptide Y cells located in the ventral arcuate nucleus. This heterogeneity in the neuropeptide Y-producing perikarya of the hypothalamus may help explain adverse neuroendocrine and behavioral effects of arcuate nucleus neuropeptide Y.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS
Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276
Self-citationNeuropeptide Regulation of Appetite and Weight*
MORLEY, J. E. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-3-256 · Cited by 589
GABA: A dominant neurotransmitter in the hypothalamus
Decavel, C., & Van Den Pol, A. N. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903020423 · Cited by 571
Oertel, W. H., Schmechel, D. E., Tappaz, M. L., & Kopin, I. J. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90113-5 · Cited by 419
Hendry, S., Jones, E., & Emson, P. (1984) · The Journal of Neuroscience · doi:10.1523/jneurosci.04-10-02497.1984 · Cited by 415
Holets, V. R., Hökfelt, T., Rökaeus, Å., Terenius, L., & Goldstein, M. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90076-0 · Cited by 367
Glutamic Acid Decarboxylase-Containing Axons Synapse on LHRH Neurons in the Rat Medial Preoptic Area
Leranth, C., MacLusky, N. J., Sakamoto, H., Shanabrough, M., & Naftolin, F. (1985) · Neuroendocrinology · doi:10.1159/000124127 · Cited by 272
Self-citationSp, K., & Wr, C. (1992) · PubMed · Cited by 232
Meister, B., Ceccatelli, S., H�kfelt, T., And�n, N. E., And�n, M., & Theodorsson, E. (1989) · Experimental Brain Research · doi:10.1007/bf00247894 · Cited by 177
Horvath, T. L., Naftolin, F., Kalra, S. P., & Leranth, C. (1992) · Endocrinology · doi:10.1210/endo.131.5.1425443 · Cited by 161
Self-citation
Cited by
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Self-citationDendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature · doi:10.1038/nature07181 · Cited by 710
Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective
Horváth, T. L., Diano, S., Sótonyi, P., Heiman, M. L., & Tschöp, M. H. (2001) · Endocrinology · doi:10.1210/en.142.10.4163 · Cited by 567
Metadata
- Authors
- Horvath, T. L., Bechmann, I., Naftolin, F., Kalra, S. P., & Leranth, C.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 756
- Issue
- 1-2
- Pages
- 283-286
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1988005306
- Cited by
- 301
- References
- 19
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. https://app.cochat.ai/papers/10.1016/s0006-8993(97)00184-4
- The paper
- Horvath, T. L., Bechmann, I., Naftolin, F., Kalra, S. P., & Leranth, C. (1997). Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Research. https://doi.org/10.1016/s0006-8993(97)00184-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
