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Immunohistochemical localization of connective tissue growth factor in the rat central nervous system
Abstract
Connective tissue growth factor (CTGF) is an immediate early growth-responsive gene but its distribution and significance in the central nervous system (CNS) are unknown. We investigated the distribution of CTGF-like immunoreactivity (CTGF-IR) in the rat CNS using a specific antiserum against CTGF oligopeptide. The majority of CTGF-IR was observed in astrocytes. Ependymal cells lining the wall of the cerebral ventricle and tanycytes lining the central canal of the spinal cord showed the strongest CTGF-IR, while there was a diffuse but weak signal in the gray matter of the spinal cord. CTGF-IR was also detected in the cytoplasm of a subpopulation of pyramidal neurons in the cerebral cortex. Our results showed that CTGF-IR is widely distributed in the CNS at both regional and cellular levels, suggesting a complex functional role in the CNS.
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CTGF is found in glial cells and cortical neurons of both rat and human brains.
“Notably, CTGF is also found in glial cells and cortical neurons of both rat and human brains (16)(17)(18).”
From Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia (2017) · cites this paper as [16]
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Cited by
Sorted by citations
Yang, C.-N., Wu, M.-F., Liu, C.-C., Jung, W.-H., Chang, Y.-C., Lee, W.-P., Shiao, Y.-J., Wu, C.-L., Liou, H.-H., Lin, S.-K., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx278 · Cited by 27
Metadata
- Authors
- Kondo, Y., Nakanishi, T., Takigawa, M., & Ogawa, N.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 834
- Issue
- 1-2
- Pages
- 146-151
- ISSN
- 0006-8993
- Cited by
- 36
- References
- 0
- Language
- en
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
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