Cited by 147Cardiomyopathy and Myosin StudiesCardiovascular Function and Risk FactorsCardiac electrophysiology and arrhythmias

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The effect of myosin light chain 2 dephosphorylation on Ca-sensitivity of force is enhanced in failing human hearts

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VANDERVELDEN, J, PAPP, Z, BOONTJE, N, ZAREMBA, R, DEJONG, J, JANSSEN, P, HASENFUSS, G, STIENEN, G·2003·Cardiovascular Research

DOI 10.1016/s0008-6363(02)00662-4

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Abstract

OBJECTIVE: Phosphorylation of the myosin light chain 2 (MLC-2) isoform expressed as a percentage of total MLC-2 was decreased in failing (21.1+/-2.0%) compared to donor (31.9+/-4.8%) hearts. To assess the functional implications of this change, we compared the effects of MLC-2 dephosphorylation on force development in failing and non-failing (donor) human hearts. METHODS: Cooperative effects in isometric force and rate of force redevelopment (K(tr)) were studied in single Triton-skinned human cardiomyocytes at various [Ca(2+)] before and after protein phosphatase-1 (PP-1) incubation. RESULTS: Maximum force and K(tr) values did not differ between failing and donor hearts, but Ca(2+)-sensitivity of force (pCa(50)) was significantly higher in failing myocardium (Deltap Ca(50)=0.17). K(tr) decreased with decreasing [Ca(2+)], although this decrease was less in failing than in donor hearts. Incubation of the myocytes with PP-1 (0.5 U/ml; 60 min) decreased pCa(50) to a larger extent in failing (0.20 pCa units) than in donor cardiomyocytes (0.10 pCa units). A decrease in absolute K(tr) values was found after PP-1 in failing and donor myocytes, while the shape of the K(tr)-Ca(2+) relationships remained unaltered. CONCLUSIONS: Surprisingly, the contractile response to MLC-2 dephosphorylation is enhanced in failing hearts, despite the reduced level of basal MLC-2 phosphorylation. The enhanced response to MLC-2 dephosphorylation in failing myocytes might result from differences in basal phosphorylation of other thin and thick filament proteins between donor and failing hearts. Regulation of Ca(2+)-sensitivity via MLC-2 phosphorylation may be a potential compensatory mechanism to reverse the detrimental effects of increased Ca(2+)-sensitivity and impaired Ca(2+)-handling on diastolic function in human heart failure.

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Authors: VANDERVELDEN, J., PAPP, Z., BOONTJE, N., ZAREMBA, R., DEJONG, J., JANSSEN, P., HASENFUSS, G., & STIENEN, G.
Affiliations: University of Debrecen (HU)
Amsterdam Cardiovascular Sciences (NL)
Vrije Universiteit Amsterdam (NL)
Erasmus University Rotterdam (NL)
University of Göttingen (DE)
ORCID: PAPP, Z
JANSSEN, P
HASENFUSS, G
STIENEN, G
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2003-02-01
Volume: 57
Issue: 2
Pages: 505-514
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1016/s0008-6363(02)00662-4
OpenAlex: W2070092583
Cited by: 147
References: 34
Citations by year: 2026: 6 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 12 · 2014: 10 · 2013: 9 · 2012: 6
FWCI: 5.05
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
GRO (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: myosin light chain 2, calcium sensitivity of contraction, heart failure, protein phosphatase 1, human cardiomyocytes, thin filament regulation, compensatory mechanisms, diastolic function, calcium handling
MeSH terms: Adult, Calcium, Cells, Cultured, Female, Heart Failure, Humans, Male, Middle Aged, Myocardial Contraction, Phosphoprotein Phosphatases, Phosphorylation, Electrophoresis, Gel, Two-Dimensional, Myosin Light Chains, Cardiac Myosins, Myocytes, Cardiac, Protein Phosphatase 1

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The effect of myosin light chain 2 dephosphorylation on Ca-sensitivity of force is enhanced in failing human hearts

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