Adrenal cortical carcinoma: survival after radiotherapy
Abstract
This study describes 15 patients with histologically proven adrenal cortical carcinoma seen at one radiotherapy centre between 1968 and 1981. Nine patients had radiotherapy following surgery and their 10 year uncorrected survival was 33%. Prognostic factors included age at diagnosis, hormone production and complete surgical removal. Two of the three long term survivors developed second malignancies.
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Radiotherapy has been shown in several recent series to offer a significant improvement in disease control in both adjuvant and palliative settings, although such improvement has not been universally demonstrated.
“Although traditionally considered ineffective for ACC (327–331), radiotherapy has been shown in several recent series to offer a significant improvement in disease control in both the adjuvant and palliative settings (247, 332–337), although such an improvement has not been universally demonstrated (338).”
From Adrenocortical carcinoma (2014) · cites this paper as [337]
Magee et al found palliative radiotherapy effective in 4 of 6 patients, either reducing tumor mass or ameliorating symptoms of hormone excess.
“Magee et al (337) found that palliative radiotherapy was effective in 4 of 6 patients, either reducing the mass of their tumors or ameliorating symptoms of hormone excess associated with a functional tumor.”
From Adrenocortical carcinoma (2014) · cites this paper as [337]
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References 5 · Cited by 34
- Authors
- Magee, B. J., Gattamaneni, H. R., & Pearson, D.
- Affiliations
- Cancer Research UK Manchester Institute (GB)
- Venue
- Clinical Radiology
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 38
- Issue
- 6
- Pages
- 587-588
- ISSN
- 0009-9260 (ISSN-L)
- OpenAlex
- W2115699942
- Cited by
- 34
- References
- 5
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 1 · 2018: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
- Keywords
- adrenocortical carcinoma, radiotherapy, survival, prognostic factors, age at diagnosis, hormone production, R0 resection, secondary malignancies, long-term survivors
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Cortex Neoplasms, Adult, Age Factors, Aged, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Prognosis, Radiotherapy, High-Energy
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