A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT1A receptor agonist 8-OH-DPAT-elicited hyperphagia in rats
Abstract
The effects of the neuronal nitric oxide (NO) synthase inhibitor 7-nitroindazole on 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)-induced hyperphagia, which is mediated by the 5-HT1A autoreceptor, were investigated in rats. 7-Nitroindazole suppressed 8-OH-DPAT-elicited increases in food intake. The inhibitory effects of 7-nitroindazole on 8-OH-DPAT-induced feeding were prevented by the NO precursor L-arginine. Although 8-OH-DPAT decreases 5-hydroxytryptamine (5-HT) synthesis, 7-nitroindazole did not reverse the 8-OH-DPAT-elicited decrease in 5-HT synthesis. Therefore, these results indicate that NO formed in the brain is involved in 8-OH-DPAT-induced hyperphagia and that the hypophagic effects of 7-nitroindazole are not dependent on 5-HT synthesis.
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NO produced in the brain antagonizes anorectic signals and stimulates food intake.
“Taken together with numerous other studies demonstrating a role for NO in the regulation of hunger [266-270], it would appear that NO produced in the brain antagonizes anorectic signals and stimulates food intake.”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [267]
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References 27 · Cited by 16
- Authors
- Sugimoto, Y., Yamada, J., & Yoshikawa, T.
- Affiliations
- Kobe Pharmaceutical University (JP)
- Corresponding author
- Sugimoto, Yumi
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 376
- Issue
- 1-2
- Pages
- 1-5
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1985338085
- Cited by
- 16
- References
- 27
- Citations by year
- 2024: 1 · 2022: 1 · 2016: 1 · 2014: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 7-nitroindazole, neuronal nitric oxide synthase inhibition, 5-HT1A receptor, 8-OH-DPAT, hyperphagia, dietary intake, nitric oxide, L-arginine, serotonin synthesis, serotonin autoreceptors, appetite regulation
- MeSH terms
- Animals, Arginine, Enzyme Inhibitors, Feeding Behavior, Hyperalgesia, Hypothalamus, Indazoles, Male, Neurons, Receptors, Serotonin, Serotonin, Rats, Sprague-Dawley, Serotonin Receptor Agonists, 8-Hydroxy-2-(di-n-propylamino)tetralin, Autoreceptors, Nitric Oxide Synthase, Receptors, Serotonin, 5-HT1, Rats
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