Differential changes in accumbens shell and core dopamine in behavioral sensitization to nicotine
Abstract
Repeated treatment with nicotine has been shown to sensitize rats to its locomotor stimulant effects and to its properties to stimulate mesolimbic dopamine transmission. We investigated the relationship between sensitization of nicotine induced locomotor stimulation and activation of dopamine transmission in the nucleus accumbens shell and core. Rats were administered daily for 5 days with 0.4 mg/kg s.c. of nicotine or with saline and 24 h later, dopamine was monitored by microdialysis in the shell and in the core of nucleus accumbens and behavioral activity was scored after challenge with nicotine (0. 4 mg/kg s.c.). Behavioral sensitization to nicotine was associated with a reduced response of dopamine transmission in the shell and with an increased one in the core of nucleus accumbens.
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Sensitization caused by repeated drug use has been observed with many drugs of abuse, including alcohol and nicotine.
“Sensitization caused by repeated drug use has been observed with many drugs of abuse, including alcohol and nicotine (Benwell & Balfour, 1992; Cadoni & Di Chiara, 2000; Govind, Vezina, & Green, 2009; Laviolette & van der Kooy, 2004).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Cadoni & Di Chiara, 2000
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References 9 · Cited by 180
- Authors
- Cadoni, C., & Di Chiara, G.
- Affiliations
- University of Cagliari (IT)
- ORCID
- Cadoni, Cristina
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 387
- Issue
- 3
- Pages
- R23-R25
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2056217660
- Cited by
- 180
- References
- 9
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 12
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Ministero dell'Università e della Ricerca
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, behavioral sensitization, nucleus accumbens shell, nucleus accumbens core, dopamine signaling, mesolimbic dopamine system, locomotor stimulation, microdialysis
- MeSH terms
- Animals, Dopamine, Male, Motor Activity, Nicotine, Nucleus Accumbens, Rats, Sprague-Dawley, Microdialysis, Rats
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