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Cited by 41Multiple Sclerosis Research StudiesViral Infections and Immunology ResearchPeripheral Neuropathies and Disorders

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More severe neurologic deficits in SJL/J male than female mice following Theiler’s virus-induced CNS demyelination

Alley, Jeremy, Khasabov, Sergey, Simone, Don, Beitz, Alvin, Rodriguez, Moses, Njenga, M.Kariuki·2003·Experimental Neurology
DOI 10.1016/s0014-4886(02)00054-7
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Abstract

Although multiple sclerosis (MS) is more prevalent in women than men, male MS patients develop more severe clinical symptoms and deteriorate faster than female patients. We investigated the differences in CNS demyelinating disease between SJL/J male and female mice following Theiler's murine encephalomyelitis virus (TMEV) infection. Infected female mice had consistently higher serum levels of virus-specific IgG at 14 and 21 days and and 7 months postinfection, which resulted in less infectious virus in CNS. All male mice infected for 6 to 7 months developed paralysis, with 50% displaying bilateral posterior limb paralysis, whereas 77% of age-matched female mice were paralyzed, all displaying unilateral posterior limb paralysis. Male mice infected for 6 to 7 months performed up to threefold fewer spontaneous horizontal and vertical movements (activity box test) compared to infected age-matched females. In addition, infected male mice performed the coordination and balance (Rotarod) test at 27 +/- 4% of the expected level (expressed as a percentage of that of uninfected age-matched mice), whereas infected female mice performed at 41 +/- 5% of the expected level. Male mice had a small increase in the extent of spinal cord white matter demyelination analyzed at both 45 days and between 6 and 7 months postinfection. For individual male and female mice, the extent of demyelination had a negative linear relationship with the neurologic performances. The emergence of a disease paradi…

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Metadata

Authors
Alley, J., Khasabov, S., Simone, D., Beitz, A., Rodriguez, M., & Njenga, M. K.
Affiliations
  • University of Minnesota (US)
  • Mayo Clinic (US)
Corresponding author
Njenga, M.Kariuki
ORCID
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
2003-03
Volume
180
Issue
1
Pages
14-24
ISSN
0014-4886 (ISSN-L)
DOI
10.1016/s0014-4886(02)00054-7
OpenAlex
W2033534190
Cited by
41
References
48
Citations by year
2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 2 · 2015: 2 · 2014: 1 · 2012: 2
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Minnesota
  • National Institute of Neurological Disorders and Stroke (R01NS032129, NS32129)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords
multiple sclerosis, sex differences, Theiler's murine encephalomyelitis virus, central nervous system demyelination, neurological deficit, paralysis, motor coordination, balance, spinal cord white matter, autoimmune disease, SJL/J mice
MeSH terms
Acute Disease, Animals, Antibodies, Viral, Behavior, Animal, Central Nervous System, Chronic Disease, Demyelinating Diseases, Disease Models, Animal, Female, Male, Motor Activity, Multiple Sclerosis, Paralysis, Viral Plaque Assay, Sex Factors, Spinal Cord, Theilovirus, Cardiovirus Infections, Disease Progression, Mice

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