Antioxidant α‐tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes
Abstract
We have shown recently that oxidative stress by chronic hyperglycemia damages the pancreatic β‐cells of GK rats, a model of non‐obese type 2 diabetes, which may worsen diabetic condition and suggested the administration of antioxidants as a supportive therapy. To determine if natural antioxidant α‐tocopherol (vitamin E) has beneficial effects on the glycemic control of type 2 diabetes, GK rats were fed a diet containing 0, 20 or 500 mg/kg diet α‐tocopherol. Intraperitoneal glucose tolerance test revealed a significant increment of insulin secretion at 30 min and a significant decrement of blood glucose levels at 30 and 120 min after glucose loading in the GK rats fed with high α‐tocopherol diet. The levels of glycated hemoglobin A1c, an indicator of glycemic control, were also reduced. Vitamin E supplementation clearly ameliorated diabetic control of GK rats, suggesting the importance of not only dietary supplementation of natural antioxidants but also other antioxidative intervention as a supportive therapy of type 2 diabetic patients.
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Vitamin E controls hyperglycemia and lowers HbA1c by suppressing oxidative stress in rats.
“In another rat experiment, vitamin E has been shown to control hyperglycemia and lower glycated hemoglobin, and HbA1c, by suppressing the oxidative stress level (Ihara et al. 2000).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ihara et al. 2000
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References 35 · Cited by 124
- Authors
- Ihara, Y., Yamada, Y., Toyokuni, S., Miyawaki, K., Ban, N., Adachi, T., Kuroe, A., Iwakura, T., Kubota, A., Hiai, H., & Seino, Y.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Ihara, Yu
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-05
- Volume
- 473
- Issue
- 1
- Pages
- 24-26
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2006722973
- Cited by
- 124
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- alpha-tocopherol, vitamin E, type 2 diabetes, glycemic control, Goto-Kakizaki rats, oxidative stress, hyperglycemia, pancreatic beta cells, insulin secretion, glucose tolerance, HbA1c, antioxidant supplementation, dietary supplementation
- MeSH terms
- Animals, Antioxidants, Blood Glucose, Body Weight, Diabetes Mellitus, Type 2, Disease Models, Animal, Fasting, Glucose, Glucose Tolerance Test, Glycated Hemoglobin, Insulin, Male, Pancreas, Rats, Inbred Strains, Vitamin E, Dietary Supplements, Rats
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